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Rabbit Anti-VAPB Antibody (CSB-PA025790ESR2HU)
Supplier: CUSABIO BIOTECH CO.
VAMP-B/VAMP-C Antibody,VAMP-associated protein B/C Antibody,VAP-B/VAP-C Antibody,VAPB Antibody,UNQ484/PRO983 AntibodyMore alternative names for the antibody
ALS 8 antibody|ALS8 antibody|D2Abb2e antibody|UNQ484/PRO983 antibody|Vamp 33b antibody|VAMP associated 33 kDa protein antibody|VAMP associated protein B and C antibody|VAMP associated protein B antibody|VAMP associated protein B/C antibody|VAMP associated protein C antibody|VAMP B antibody|VAMP B VAMP C antibody|VAMP B/VAMP C antibody|VAMP C antibody|VAMP vesicle associated membrane protein associated protein B and C antibody|Vamp33b antibody|VAMPB antibody|VAMPB/VAMPC antibody|VAMPC antibody|VAP 33b antibody|VAP B antibody|VAP B/VAP C antibody|VAP C antibody|VAP33b antibody|VAPB/VAPC antibody|VAPC antibody|Vesicle associated membrane protein associated protein B and C antibody|Vesicle associated membrane protein associated protein B/C antibody
Anti-VAPB antibody [MM0949-33M9] (ab201634)
Anti-VAPB antibody [MM0949-33M9] (ab201634)
Recommended applications: ELISA, WB
Recommended dilution: Recommended dilution:WB:1:500-5000
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Vesicle-associated membrane protein-associated protein B/C protein (10-222AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:326580( Cow), Entrez Gene:9217( Human), Entrez Gene:56491( Mouse), Entrez Gene:100144536( Pig), Entrez Gene:60431( Rat), Omim:605704( Human), SwissProt:A2VDZ9( Cow), SwissProt:O95292( Human), SwissProt:Q9QY76( Mouse), SwissProt:A5GFS8( Pig), SwissProt:Q9Z269( Rat), Unigene:182625( Human), Unigene:260456( Mouse), Unigene:52500( Rat)
|Protein function|| |
Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation. .
|Protein tissue specificity|| |
Ubiquitous. Isoform 1 predominates.
|Involvement in disease|| |
Amyotrophic lateral sclerosis 8 (ALS8) [MIM:608627]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Spinal muscular atrophy, proximal, adult, autosomal dominant (SMAPAD) [MIM:182980]: A form of spinal muscular atrophy, a neuromuscular disorder characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. SMAPAD is characterized by proximal muscle weakness that begins in the lower limbs and then progresses to upper limbs, onset in late adulthood (after third decade) and a benign course. Most of the patients remain ambulatory 10 to 40 years after clinical onset. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.
|Protein cellular localization|| |
Endoplasmic reticulum membrane ; Single-pass type IV membrane protein . Note=Present in mitochondria-associated membranes that are endoplasmic reticulum membrane regions closely apposed to the outer mitochondrial membrane. .
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CUSABIO BIOTECH CO.
|Product type|| |
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