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Rabbit Anti-VPS11 Antibody (CSB-PA887959ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Vacuolar protein sorting-associated protein 11 homolog Antibody,hVPS11 Antibody,RING finger protein 108 Antibody,VPS11 Antibody,RNF108 Antibody,PP3476 AntibodyMore alternative names for the antibody
END1 antibody|HGNC:14583 antibody|hVPS11 antibody|PEP5 antibody|PP3476 antibody|RING finger protein 108 antibody|RNF108 antibody|Vacuolar protein sorting 11 (yeast homolog) antibody|Vacuolar protein sorting 11 (yeast) antibody|Vacuolar protein sorting 11 homolog (S. cerevisiae) antibody|Vacuolar protein sorting 11 homolog antibody|Vacuolar protein sorting associated protein 11 homolog antibody|Vacuolar protein sorting protein 11 antibody|Vacuolar protein sorting-associated protein 11 homolog antibody|vps11 antibody|VPS11_HUMAN antibody
Anti-VPS11 antibody [EPR10345] (ab170869)
Anti-VPS11 antibody [EPR10345] (ab170869)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Vacuolar protein sorting-associated protein 11 homolog protein (692-941AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:55823( Human), Entrez Gene:71732( Mouse), Entrez Gene:315600( Rat), Omim:608549( Human), SwissProt:Q9H270( Human), SwissProt:Q91W86( Mouse), Unigene:234282( Human), Unigene:295013( Mouse), Unigene:2637( Rat)
|Protein function|| |
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PubMed:21148287). Involved in the retrograde Shiga toxin transport (PubMed:23593995). .
|Protein tissue specificity|| |
Ubiquitous. Expression was highest in heart and low in lung.
|Involvement in disease|| |
Leukodystrophy, hypomyelinating, 12 (HLD12) [MIM:616683]: An autosomal recessive neurologic disorder characterized by developmental delay, spasticity, truncal hypotonia, acquired microcephaly, intellectual disability with variable seizure disorder, accompanied by thin corpus callosum, paucity of white matter and delayed myelination. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the VPS11 family.
|Protein cellular localization|| |
Endosome . Late endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Lysosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Early endosome . Cytoplasmic vesicle . Cytoplasmic vesicle, autophagosome . Cytoplasmic vesicle, clathrin-coated vesicle .
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CUSABIO BIOTECH CO.
|Product type|| |
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