Anti-VPS11 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-VPS11 Antibody (CSB-PA887959ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Vacuolar protein sorting-associated protein 11 homolog Antibody,hVPS11 Antibody,RING finger protein 108 Antibody,VPS11 Antibody,RNF108 Antibody,PP3476 Antibody

More alternative names for the antibody
END1 antibody|HGNC:14583 antibody|hVPS11 antibody|PEP5 antibody|PP3476 antibody|RING finger protein 108 antibody|RNF108 antibody|Vacuolar protein sorting 11 (yeast homolog) antibody|Vacuolar protein sorting 11 (yeast) antibody|Vacuolar protein sorting 11 homolog (S. cerevisiae) antibody|Vacuolar protein sorting 11 homolog antibody|Vacuolar protein sorting associated protein 11 homolog antibody|Vacuolar protein sorting protein 11 antibody|Vacuolar protein sorting-associated protein 11 homolog antibody|vps11 antibody|VPS11_HUMAN antibody
Anti-VPS11 antibody [EPR10345] (ab170869)
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Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-VPS11 Antibody

Catalogue No.

CSB-PA887959ESR2HU

Reactivity

Human

Immunogen

Recombinant human Vacuolar protein sorting-associated protein 11 homolog protein (692-941AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

107 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:55823( Human), Entrez Gene:71732( Mouse), Entrez Gene:315600( Rat), Omim:608549( Human), SwissProt:Q9H270( Human), SwissProt:Q91W86( Mouse), Unigene:234282( Human), Unigene:295013( Mouse), Unigene:2637( Rat)

Protein function

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PubMed:21148287). Involved in the retrograde Shiga toxin transport (PubMed:23593995). .

Protein tissue specificity

Ubiquitous. Expression was highest in heart and low in lung.

Involvement in disease

Leukodystrophy, hypomyelinating, 12 (HLD12) [MIM:616683]: An autosomal recessive neurologic disorder characterized by developmental delay, spasticity, truncal hypotonia, acquired microcephaly, intellectual disability with variable seizure disorder, accompanied by thin corpus callosum, paucity of white matter and delayed myelination. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the VPS11 family.

Protein cellular localization

Endosome . Late endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Lysosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Early endosome . Cytoplasmic vesicle . Cytoplasmic vesicle, autophagosome . Cytoplasmic vesicle, clathrin-coated vesicle .

Research area

All research areas>Signaling Intermediates>VPS
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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