Anti-VPS33B Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-VPS33B Antibody (CSB-PA884447ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Vacuolar protein sorting-associated protein 33B Antibody,hVPS33B Antibody,VPS33B Antibody

More alternative names for the antibody
FLJ14848 antibody|hVPS 33B antibody|hVPS33B antibody|Vacuolar protein sorting 33 homolog B (yeast) antibody|Vacuolar protein sorting 33 homolog B antibody|Vacuolar protein sorting 33B (yeast) antibody|Vacuolar protein sorting 33B antibody|Vacuolar protein sorting associated protein 33B antibody|VPS 33B antibody
Anti-VPS33B antibody (ab153844)
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Recommended applications: ELISA, WB, IHC

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-VPS33B Antibody

Catalogue No.

CSB-PA884447ESR2HU

Reactivity

Human

Immunogen

Recombinant human Vacuolar protein sorting-associated protein 33B protein (348-617AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

70 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:25858( Chicken), Entrez Gene:526538( Cow), Entrez Gene:26276( Human), Entrez Gene:233405( Mouse), Entrez Gene:64060( Rat), Omim:608552( Human), SwissProt:Q2HJ18( Cow), SwissProt:Q9H267( Human), SwissProt:P59016( Mouse), SwissProt:Q63616( Rat)

Protein function

May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages (PubMed:18474358). Proposed to be involved in endosomal maturation implicating VIPAS39. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). Seems to be involved in the sorting of specific cargos from the trans-Golgi network to alpha-granule-destined multivesicular bodies (MVBs) promoting MVBs maturation in megakaryocytes (By similarity). .

Protein tissue specificity

Ubiquitous; highly expressed in testis and low expression in the lung.

Involvement in disease

Arthrogryposis, renal dysfunction and cholestasis syndrome 1 (ARCS1) [MIM:208085]: A multisystem disorder, characterized by neurogenic arthrogryposis multiplex congenita, renal tubular dysfunction and neonatal cholestasis with bile duct hypoplasia and low gamma glutamyl transpeptidase activity. Platelet dysfunction is common. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the STXBP/unc-18/SEC1 family.

Protein post-translational modifications

Phosphorylated on tyrosine residues. Dephosphorylation by M.tuberculosis PtpA is necessary to induce the reduction of host phagolysosome fusion in M.tuberculosis-infected macrophages. .

Protein cellular localization

Late endosome membrane ; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane ; Peripheral membrane protein; Cytoplasmic side. Early endosome . Cytoplasmic vesicle, clathrin-coated vesicle . Recycling endosome . Note=Colocalizes in clusters with VIPAS39 at cytoplasmic organelles (PubMed:19109425). Colocalizes with RAB11A and VIPAS39 on recycling endosomes (PubMed:22753090). Colocalizes with AP-3, clathrin, Rab5 and Rab7b (PubMed:21411634). Colocalizes with M.tuberculosis PtpA in the cytosol of tuberculosis-infected macrophages and associates with phagosomes (PubMed:18474358). .

Research area

All research areas>Signaling Intermediates>VPS
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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