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Rabbit Anti-VPS33B Antibody (CSB-PA884447ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Vacuolar protein sorting-associated protein 33B Antibody,hVPS33B Antibody,VPS33B AntibodyMore alternative names for the antibody
FLJ14848 antibody|hVPS 33B antibody|hVPS33B antibody|Vacuolar protein sorting 33 homolog B (yeast) antibody|Vacuolar protein sorting 33 homolog B antibody|Vacuolar protein sorting 33B (yeast) antibody|Vacuolar protein sorting 33B antibody|Vacuolar protein sorting associated protein 33B antibody|VPS 33B antibody
Anti-VPS33B antibody (ab153844)
Anti-VPS33B antibody (ab153844)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Vacuolar protein sorting-associated protein 33B protein (348-617AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:25858( Chicken), Entrez Gene:526538( Cow), Entrez Gene:26276( Human), Entrez Gene:233405( Mouse), Entrez Gene:64060( Rat), Omim:608552( Human), SwissProt:Q2HJ18( Cow), SwissProt:Q9H267( Human), SwissProt:P59016( Mouse), SwissProt:Q63616( Rat)
|Protein function|| |
May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages (PubMed:18474358). Proposed to be involved in endosomal maturation implicating VIPAS39. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). Seems to be involved in the sorting of specific cargos from the trans-Golgi network to alpha-granule-destined multivesicular bodies (MVBs) promoting MVBs maturation in megakaryocytes (By similarity). .
|Protein tissue specificity|| |
Ubiquitous; highly expressed in testis and low expression in the lung.
|Involvement in disease|| |
Arthrogryposis, renal dysfunction and cholestasis syndrome 1 (ARCS1) [MIM:208085]: A multisystem disorder, characterized by neurogenic arthrogryposis multiplex congenita, renal tubular dysfunction and neonatal cholestasis with bile duct hypoplasia and low gamma glutamyl transpeptidase activity. Platelet dysfunction is common. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the STXBP/unc-18/SEC1 family.
|Protein post-translational modifications|| |
Phosphorylated on tyrosine residues. Dephosphorylation by M.tuberculosis PtpA is necessary to induce the reduction of host phagolysosome fusion in M.tuberculosis-infected macrophages. .
|Protein cellular localization|| |
Late endosome membrane ; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane ; Peripheral membrane protein; Cytoplasmic side. Early endosome . Cytoplasmic vesicle, clathrin-coated vesicle . Recycling endosome . Note=Colocalizes in clusters with VIPAS39 at cytoplasmic organelles (PubMed:19109425). Colocalizes with RAB11A and VIPAS39 on recycling endosomes (PubMed:22753090). Colocalizes with AP-3, clathrin, Rab5 and Rab7b (PubMed:21411634). Colocalizes with M.tuberculosis PtpA in the cytosol of tuberculosis-infected macrophages and associates with phagosomes (PubMed:18474358). .
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CUSABIO BIOTECH CO.
|Product type|| |
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