Anti-VPS4A Antibody

$99.00$319.00

Reactivity: Human,Mouse,Rat
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-VPS4A Antibody (CSB-PA891974DSR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Vacuolar protein sorting-associated protein 4A Antibody,Protein SKD2 Antibody,VPS4-1 Antibody,hVPS4 Antibody,VPS4A Antibody

More alternative names for the antibody
hVPS4 antibody|Protein SKD2 antibody|SKD1 antibody|SKD1 homolog antibody|SKD1A antibody|SKD2 antibody|Vacuolar protein sorting 4 homolog A antibody|Vacuolar protein sorting 4, yeast, homolog of, A antibody|Vacuolar protein sorting factor 4A antibody|Vacuolar protein sorting-associated protein 4A antibody|vacuolar sorting protein 4 antibody|VPS4 antibody|VPS4-1 antibody|Vps4a antibody|VPS4A_HUMAN antibody
Anti-VPS4a antibody [EPR14545(B)] (ab180581)
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Recommended applications: ELISA, WB, IHC

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-VPS4A Antibody

Catalogue No.

CSB-PA891974DSR2HU

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant human Vacuolar protein sorting-associated protein 4A protein (1-120AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

48 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:27183( Human), Entrez Gene:116733( Mouse), Entrez Gene:246772( Rat), Omim:609982( Human), SwissProt:Q9UN37( Human), SwissProt:Q8VEJ9( Mouse), SwissProt:Q793F9( Rat), Unigene:128420( Human), Unigene:236004( Mouse), Unigene:12477( Rat)

Protein function

Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Involved in cytokinesis: retained at the midbody by ZFYVE19/ANCHR and CHMP4C until abscission checkpoint signaling is terminated at late cytokinesis. It is then released following dephosphorylation of CHMP4C, leading to abscission (PubMed:24814515). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). .

Protein tissue specificity

Ubiquitously expressed. .

Protein sequence and domain

Belongs to the AAA ATPase family. The MIT domain serves as an adapter for ESCRT-III proteins. It forms an asymmetric three-helix bundle that binds amphipathic MIM (MIT interacting motif) helices along the groove between MIT helices 2 and 3 present in a subset of ESCRT-III proteins thus establishing the canonical MIM-MIT interaction. In an extended conformation along the groove between helices 1 and 3, also binds to a type-2 MIT interacting motif (MIM2).

Protein cellular localization

Prevacuolar compartment membrane; Peripheral membrane protein. Late endosome membrane ; Peripheral membrane protein . Midbody. Note=Membrane-associated in the prevacuolar endosomal compartment. Localizes to the midbody of dividing cells, interaction with ZFYVE19/ANCHR mediates retention at midbody (PubMed:24814515). Localized in two distinct rings on either side of the Flemming body. .

Research area

All research areas>Signaling Intermediates>VPS
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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