Anti-VRK1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-VRK1 Antibody (CSB-PA857466DSR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Serine/threonine-protein kinase VRK1 Antibody,Vaccinia-related kinase 1 Antibody,VRK1 Antibody

More alternative names for the antibody
MGC117401 antibody|VRK1 antibody|VRK1_HUMAN antibody
Anti-VRK1 antibody [5D1] – N-terminal (ab171933)
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Recommended applications: ELISA, WB, IHC

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-VRK1 Antibody

Catalogue No.

CSB-PA857466DSR1HU

Reactivity

Human

Immunogen

Recombinant human Serine/threonine-protein kinase VRK1 protein (257-396AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

45 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:7443( Human), Omim:602168( Human), SwissProt:Q99986( Human), Unigene:422662( Human)

Protein function

Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates ‘Thr-18’ of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity. .

Protein tissue specificity

Widely expressed. Highly expressed in fetal liver, testis and thymus. .

Involvement in disease

Pontocerebellar hypoplasia 1A (PCH1A) [MIM:607596]: A disorder characterized by an abnormally small cerebellum and brainstem, central and peripheral motor dysfunction from birth, gliosis and spinal cord anterior horn cells degeneration resembling infantile spinal muscular atrophy. Additional features include muscle hypotonia, congenital contractures and respiratory insufficiency that is evident at birth. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.

Protein post-translational modifications

Autophosphorylated at various serine and threonine residues. Autophosphorylation does not impair its ability to phosphorylate p53/TP53. Phosphorylation by PLK3 leads to induction of Golgi fragmentation during mitosis. .

Protein cellular localization

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle . Note=Dispersed throughout the cell but not located on mitotic spindle or chromatids during mitosis.

Research area

All research areas>Kinases and Phosphatases>VRK
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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