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Rabbit Anti-WIPI1 Antibody (CSB-PA705810ESR2HU)
Supplier: CUSABIO BIOTECH CO.
WIPI-1 Antibody,Atg18 protein homolog Antibody,WD40 repeat protein interacting with phosphoinositides of 49 kDa Antibody,WIPI 49 kDa Antibody,WIPI1 Antibody,WIPI49 AntibodyMore alternative names for the antibody
ATG 18 antibody|ATG18 antibody|Atg18 protein homolog antibody|ATG18A antibody|FLJ10055 antibody|WD repeat domain phosphoinositide interacting 1 antibody|WD repeat domain phosphoinositide interacting protein 1 antibody|WD repeat domain phosphoinositide-interacting protein 1 antibody|WD40 repeat protein interacting with phosphoinositides of 49 kDa antibody|WD40 repeat protein interacting with phosphoInositides of 49kDa antibody|WIPI 1 alpha antibody|WIPI 1 antibody|WIPI 49 antibody|WIPI 49 kDa antibody|WIPI-1 antibody|wipi1 antibody|WIPI1_HUMAN antibody|WIPI49 antibody
Anti-WIPI1 antibody [EPR8110] (ab128901)
Anti-WIPI1 antibody [EPR8110] (ab128901)
Recommended applications: ELISA, WB, IHC
Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human WD repeat domain phosphoinositide-interacting protein 1 protein (187-446AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation-induced autophagy. May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway. .
|Protein tissue specificity|| |
Ubiquitously expressed. Highly expressed in skeletal muscle, heart, testis, pancreas and placenta. Highly expressed in G361, Sk-mel-28, Sk-mel-13, WM852 and WM451 cells. Up-regulated in a variety of tumor tissues. .
|Protein sequence and domain|| |
Belongs to the WD repeat SVP1 family. The N-terminus might form a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane. Association to the membrane can also occur through binding to phosphatidylinositol 3-monophosphate (PI3P).
|Protein cellular localization|| |
Golgi apparatus, trans-Golgi network. Endosome. Cytoplasmic vesicle, clathrin-coated vesicle. Preautophagosomal structure membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Trans elements of the Golgi and peripheral endosomes. Dynamically cycles through these compartments and is susceptible to conditions that modulate membrane flux. Enriched in clathrin-coated vesicles. Upon starvation-induced autophagy, accumulates at subcellular structures in the cytoplasm: enlarged vesicular and lasso-like structures, and large cup-shaped structures predominantly around the nucleus. Recruitment to autophagic membranes is controlled by MTMR14. Labile microtubules specifically recruit markers of autophagosome formation like WIPI1, whereas mature autophagosomes may bind to stable microtubules.
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CUSABIO BIOTECH CO.
|Product type|| |
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