Anti-WIPI2 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-WIPI2 Antibody (CSB-PA896519ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

WD repeat domain phosphoinositide-interacting protein 2 Antibody,WIPI-2 Antibody,WIPI49-like protein 2 Antibody,WIPI2 Antibody,CGI-50 Antibody

More alternative names for the antibody
ATG18B antibody|Atg21 antibody|CGI 50 antibody|DKFZp434J154 antibody|DKFZp686P02188 antibody|FLJ12979 antibody|FLJ14217 antibody|FLJ42984 antibody|WD repeat domain phosphoinositide-interacting protein 2 antibody|WD repeat domain, phosphoinositide interacting 2 antibody|WD40 repeat protein interacting with phosphoinositides 2 antibody|WIPI 2 antibody|WIPI-2 antibody|WIPI2 antibody|WIPI2_HUMAN antibody|WIPI49 like protein 2 antibody|WIPI49-like protein 2 antibody
Anti-WIPI2 antibody [2A2] (ab105459)
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Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-WIPI2 Antibody

Catalogue No.

CSB-PA896519ESR1HU

Reactivity

Human

Immunogen

Recombinant human WD repeat domain phosphoinositide-interacting protein 2 protein (205-454AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

49 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:26100( Human), Entrez Gene:74781( Mouse), Omim:609225( Human), SwissProt:Q9Y4P8( Human), SwissProt:Q80W47( Mouse), Unigene:122363( Human), Unigene:29432( Mouse)

Protein function

Early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to phosphatidylinositol 3-phosphate (PtdIns3P). May bind PtdIns3P. .; Isoform 4: Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes and preautophagosomal structures, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Isoform 4 is also required for autophagic clearance of pathogenic bacteria. Isoform 4 binds the membrane surrounding Salmonella and recruits the ATG12-5-16L1 complex, initiating LC3 conjugation, autophagosomal membrane formation, and engulfment of Salmonella. .

Protein tissue specificity

Ubiquitously expressed (at protein level). Highly expressed in heart, skeletal muscle and pancreas. Expression is down-regulated in pancreatic and in kidney tumors. .

Protein sequence and domain

Belongs to the WD repeat SVP1 family. The FRRG motif is required for recruitment to PtdIns3P.

Protein cellular localization

Preautophagosomal structure membrane ; Peripheral membrane protein ; Cytoplasmic side . Note=Localizes to omegasomes membranes which are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures. Enriched at preautophagosomal structure membranes in response to PtdIns3P. .

Research area

All research areas>Signaling Intermediates>WIPI
(View all antibody categories related to Signaling Intermediates)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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