Anti-XRCC4 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-XRCC4 Antibody (CSB-PA614413ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

X-ray repair cross-complementing protein 4 Antibody,XRCC4 Antibody

More alternative names for the antibody
DNA double strand break repair and V(D)J recombination protein XRCC4 antibody|DNA repair protein XRCC4 antibody|SSMED antibody|X ray repair complementing defective repair in Chinese hamster cells 4 antibody|X ray repair cross complementing 4 antibody|X ray repair cross complementing protein 4 antibody|X-ray repair cross-complementing protein 4 antibody|XRCC 4 antibody|XRCC4 antibody|XRCC4_HUMAN antibody
Anti-XRCC4 antibody [4H9] (ab118008)
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Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-XRCC4 Antibody

Catalogue No.

CSB-PA614413ESR2HU

Reactivity

Human

Immunogen

Recombinant human DNA repair protein XRCC4 protein (1-336AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

38 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:7518( Human), Omim:194363( Human), SwissProt:Q13426( Human), Unigene:567359( Human)

Protein function

Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. .

Protein tissue specificity

Widely expressed. .

Involvement in disease

Short stature, microcephaly, and endocrine dysfunction (SSMED) [MIM:616541]: A disease characterized by short stature and microcephaly apparent at birth, progressive postnatal growth failure, and endocrine dysfunction. In affected adults endocrine features include hypergonadotropic hypogonadism, multinodular goiter, and diabetes mellitus. Variable features observed in some patients are progressive ataxia, and lymphopenia or borderline leukopenia. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the XRCC4 family.

Protein post-translational modifications

Phosphorylated by PRKDC. The phosphorylation seems not to be necessary for binding to DNA. Phosphorylation by CK2 promotes interaction with APTX. .; Monoubiquitinated.; Sumoylation at Lys-210 is required for nuclear localization and recombination efficiency. Has no effect on ubiquitination. .

Protein cellular localization

Nucleus .

Research area

All research areas>Tumor Suppressor/Apoptosis>XRCC
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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