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Rabbit Anti-XRCC5 Antibody (CSB-PA026233DSR2HU)
Supplier: CUSABIO BIOTECH CO.
86 kDa subunit of Ku antigen Antibody,ATP-dependent DNA helicase 2 subunit 2 Antibody,ATP-dependent DNA helicase II 80 kDa subunit Antibody,CTC box-binding factor 85 kDa subunit Antibody,CTC85 Antibody,CTCBF Antibody,DNA repair protein XRCC5 Antibody,Ku80 Antibody,Ku86 Antibody,Lupus Ku autoantigen protein p86 Antibody,Nuclear factor IV Antibody,Thyroid-lupus autoantigen Antibody,TLAA Antibody,X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) Antibody,XRCC5 Antibody,G22P2 AntibodyMore alternative names for the antibody
CTC75 antibody|CTC85 antibody|CTCBF antibody|DNA repair protein XRCC5 antibody|DNA repair protein XRCC6 antibody|G22P1 antibody|G22P2 antibody|KARP1 antibody|Ku 70 antibody|Ku 80 antibody|Ku 86 antibody|Ku86 antibody|ML8 antibody|NFIV antibody|TLAA antibody|XRCC5 antibody|XRCC6 antibody
Anti-Ku70 + Ku80 antibody  (ab80828)
Anti-Ku70 + Ku80 antibody  (ab80828)
Recommended applications: ELISA, WB, IHC
Recommended dilution: Recommended dilution:WB:1:500-5000,IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human X-ray repair cross-complementing protein 5 protein (543-732AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:2547( Human), Entrez Gene:7520( Human), Entrez Gene:14375( Mouse), Entrez Gene:22596( Mouse), Entrez Gene:25019( Rat), Entrez Gene:363247( Rat), Omim:152690( Human), Omim:194364( Human), SwissProt:P12956( Human), SwissProt:P13010( Human), SwissProt:P23475( Mouse), SwissProt:P27641( Mouse)
|Protein function|| |
Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3′-5′ direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. In association with NAA15, the XRCC5/6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:20383123). The XRCC5/6 dimer probably also acts as a 5′-deoxyribose-5-phosphate lyase (5′-dRP lyase), by catalyzing the beta-elimination of the 5′ deoxyribose-5-phosphate at an abasic site near double-strand breaks. XRCC5 probably acts as the catalytic subunit of 5′-dRP activity, and allows to ‘clean’ the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). .
|Protein sequence and domain|| |
Belongs to the ku80 family. The EEXXXDDL motif is required for the interaction with catalytic subunit PRKDC and its recruitment to sites of DNA damage.
|Protein post-translational modifications|| |
Phosphorylated on serine residues. Phosphorylation by PRKDC may enhance helicase activity. .; Sumoylated. .; Ubiquitinated by RNF8 via ‘Lys-48’-linked ubiquitination following DNA damage, leading to its degradation and removal from DNA damage sites (PubMed:22266820). Ubiquitinated by RNF138, leading to remove the Ku complex from DNA breaks (PubMed:26502055). .
|Protein cellular localization|| |
Nucleus . Nucleus, nucleolus . Chromosome .
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|Product type|| |
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