Anti-XRCC5 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-XRCC5 Antibody (CSB-PA026233DSR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

86 kDa subunit of Ku antigen Antibody,ATP-dependent DNA helicase 2 subunit 2 Antibody,ATP-dependent DNA helicase II 80 kDa subunit Antibody,CTC box-binding factor 85 kDa subunit Antibody,CTC85 Antibody,CTCBF Antibody,DNA repair protein XRCC5 Antibody,Ku80 Antibody,Ku86 Antibody,Lupus Ku autoantigen protein p86 Antibody,Nuclear factor IV Antibody,Thyroid-lupus autoantigen Antibody,TLAA Antibody,X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) Antibody,XRCC5 Antibody,G22P2 Antibody

More alternative names for the antibody
CTC75 antibody|CTC85 antibody|CTCBF antibody|DNA repair protein XRCC5 antibody|DNA repair protein XRCC6 antibody|G22P1 antibody|G22P2 antibody|KARP1 antibody|Ku 70 antibody|Ku 80 antibody|Ku 86 antibody|Ku86 antibody|ML8 antibody|NFIV antibody|TLAA antibody|XRCC5 antibody|XRCC6 antibody
Anti-Ku70 + Ku80 antibody [162] (ab80828)
Close sc-53021|sc-135964|sc-5280|sc-1484|sc-9034|sc-33653|sc-1485|sc-56135|sc-56136|

Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:500-5000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-XRCC5 Antibody

Catalogue No.

CSB-PA026233DSR2HU

Reactivity

Human

Immunogen

Recombinant human X-ray repair cross-complementing protein 5 protein (543-732AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:500-5000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

82 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:2547( Human), Entrez Gene:7520( Human), Entrez Gene:14375( Mouse), Entrez Gene:22596( Mouse), Entrez Gene:25019( Rat), Entrez Gene:363247( Rat), Omim:152690( Human), Omim:194364( Human), SwissProt:P12956( Human), SwissProt:P13010( Human), SwissProt:P23475( Mouse), SwissProt:P27641( Mouse)

Protein function

Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3′-5′ direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. In association with NAA15, the XRCC5/6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:20383123). The XRCC5/6 dimer probably also acts as a 5′-deoxyribose-5-phosphate lyase (5′-dRP lyase), by catalyzing the beta-elimination of the 5′ deoxyribose-5-phosphate at an abasic site near double-strand breaks. XRCC5 probably acts as the catalytic subunit of 5′-dRP activity, and allows to ‘clean’ the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). .

Protein sequence and domain

Belongs to the ku80 family. The EEXXXDDL motif is required for the interaction with catalytic subunit PRKDC and its recruitment to sites of DNA damage.

Protein post-translational modifications

Phosphorylated on serine residues. Phosphorylation by PRKDC may enhance helicase activity. .; Sumoylated. .; Ubiquitinated by RNF8 via ‘Lys-48’-linked ubiquitination following DNA damage, leading to its degradation and removal from DNA damage sites (PubMed:22266820). Ubiquitinated by RNF138, leading to remove the Ku complex from DNA breaks (PubMed:26502055). .

Protein cellular localization

Nucleus . Nucleus, nucleolus . Chromosome .

Research area

All research areas>Tumor Suppressor/Apoptosis>Ku Lupus Antigen
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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