Anti-YME1L1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-YME1L1 Antibody (CSB-PA853509ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

ATP-dependent zinc metalloprotease YME1L1 Antibody,ATP-dependent metalloprotease FtsH1 Antibody,Meg-4 Antibody,Presenilin-associated metalloprotease Antibody,PAMP Antibody,YME1-like protein 1 Antibody,YME1L1 Antibody,FTSH1 Antibody,YME1L Antibody,UNQ1868/PRO4304 Antibody

More alternative names for the antibody

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Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-YME1L1 Antibody

Catalogue No.

CSB-PA853509ESR1HU

Reactivity

Human

Immunogen

Recombinant human ATP-dependent zinc metalloprotease YME1L1 protein (1-240AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

86 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Protein function

Putative ATP-dependent protease. Plays a role in mitochondrial organization and mitochondrial protein metabolism, including degradation of PRELID1 and OPA1 (PubMed:18076378, PubMed:27495975). Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1). .

Protein tissue specificity

High expression in cardiac and skeletal muscle mitochondria. .

Involvement in disease

Note=Defects in YME1L1 may cause a mitochondrial disorder characterized by infantile onset of intellectual disability, motor developmental delay, expressive speech delay, optic nerve atrophy associated with visual impairment, hearing impairment, but no facial dysmorphism. Lactate levels and lactate/pyruvate ratios are elevated in patients blood and/or cerebrospinal fluid. Muscle biopsy show mitochondria with altered cristae morphology and paracristalline inclusions. .

Protein sequence and domain

In the N-terminal section; belongs to the AAA ATPase family.; In the C-terminal section; belongs to the peptidase M41 family.

Protein post-translational modifications

Proteolytically processed by mitochondrial processing peptidase (MPP) to generate the mature form. .

Protein cellular localization

Mitochondrion inner membrane . Mitochondrion .

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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