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Rabbit Anti-YME1L1 Antibody (CSB-PA853509ESR1HU)
Supplier: CUSABIO BIOTECH CO.
ATP-dependent zinc metalloprotease YME1L1 Antibody,ATP-dependent metalloprotease FtsH1 Antibody,Meg-4 Antibody,Presenilin-associated metalloprotease Antibody,PAMP Antibody,YME1-like protein 1 Antibody,YME1L1 Antibody,FTSH1 Antibody,YME1L Antibody,UNQ1868/PRO4304 AntibodyMore alternative names for the antibody
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human ATP-dependent zinc metalloprotease YME1L1 protein (1-240AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Putative ATP-dependent protease. Plays a role in mitochondrial organization and mitochondrial protein metabolism, including degradation of PRELID1 and OPA1 (PubMed:18076378, PubMed:27495975). Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1). .
|Protein tissue specificity|| |
High expression in cardiac and skeletal muscle mitochondria. .
|Involvement in disease|| |
Note=Defects in YME1L1 may cause a mitochondrial disorder characterized by infantile onset of intellectual disability, motor developmental delay, expressive speech delay, optic nerve atrophy associated with visual impairment, hearing impairment, but no facial dysmorphism. Lactate levels and lactate/pyruvate ratios are elevated in patients blood and/or cerebrospinal fluid. Muscle biopsy show mitochondria with altered cristae morphology and paracristalline inclusions. .
|Protein sequence and domain|| |
In the N-terminal section; belongs to the AAA ATPase family.; In the C-terminal section; belongs to the peptidase M41 family.
|Protein post-translational modifications|| |
Proteolytically processed by mitochondrial processing peptidase (MPP) to generate the mature form. .
|Protein cellular localization|| |
Mitochondrion inner membrane . Mitochondrion .
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CUSABIO BIOTECH CO.
|Product type|| |
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