Anti-ZBTB48 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-ZBTB48 Antibody (CSB-PA026340DSR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Zinc finger and BTB domain-containing protein 48 Antibody,Krueppel-related zinc finger protein 3 Antibody,Protein HKR3 Antibody,Zinc finger protein 855 Antibody,ZBTB48 Antibody,HKR3 Antibody,ZNF855 Antibody

More alternative names for the antibody
0610011D15Rik antibody|OTTMUSP00000031803 antibody|pp9964 antibody|Protein HKR3 antibody|RP23-445E20.3 antibody|ZBT48_HUMAN antibody|ZBTB 48 antibody|Zbtb48 antibody|Zinc finger and BTB domain containing 48 antibody|Zinc finger and BTB domain containing protein 48 antibody|Zinc finger and BTB domain-containing protein 48 antibody|Zinc finger protein 855 antibody|ZNF855 antibody
Anti-ZBTB48 antibody (ab168417)
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Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-ZBTB48 Antibody

Catalogue No.

CSB-PA026340DSR1HU

Reactivity

Human

Immunogen

Recombinant human Zinc finger and BTB domain-containing protein 48 protein (1-280AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

77 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:3104( Human), Entrez Gene:100090( Mouse), Omim:165270( Human), SwissProt:P10074( Human), SwissProt:Q1H9T6( Mouse), Unigene:502330( Human), Unigene:24661( Mouse)

Protein function

Telomere-binding protein that acts as a regulator of telomere length (PubMed:28082411). Directly binds the telomeric double-stranded 5′-TTAGGG-3′ repeat (PubMed:28082411). Preferentially binds to long telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres (PubMed:28082411). Also acts as a transcription regulator that binds to promoter regions (PubMed:7969177, PubMed:24382891). Regulates expression the J and/or S elements in MHC II promoter (PubMed:7969177). Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A (PubMed:24382891). .

Protein tissue specificity

Detected in adrenal gland and neuroblastoma. .

Protein sequence and domain

Belongs to the krueppel C2H2-type zinc-finger protein family. The C2H2-type zinc fingers mediate binding to the telomeric double-stranded 5′-TTAGGG-3′ repeats (PubMed:28082411).

Protein cellular localization

Nucleus . Chromosome, telomere . Note=Directly binds the telomeric double-stranded 5′-TTAGGG-3′ repeat: preferentially binds to long telomeres that have a low concentration of shelterin complex, competing with the telomeric repeat binding factors TERF1 and TERF2 (PubMed:28082411). .

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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