Anti-ZC3HC1 Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit Anti-ZC3HC1 Antibody (CSB-PA801246ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Nuclear-interacting partner of ALK Antibody,Nuclear-interacting partner of anaplastic lymphoma kinase Antibody,hNIPA Antibody,Zinc finger C3HC-type protein 1 Antibody,ZC3HC1 Antibody,NIPA Antibody,HSPC216 Antibody

More alternative names for the antibody
hNIPA antibody|NIPA_HUMAN antibody|Nuclear interacting partner of ALK antibody|Nuclear interacting partner of anaplastic lymphoma kinase antibody|Nuclear-interacting partner of ALK antibody|Nuclear-interacting partner of anaplastic lymphoma kinase antibody|zc3hc1 antibody|Zinc finger C3HC type containing 1 antibody|Zinc finger C3HC-type protein 1 antibody
Phospho anti-NIPA (S354) antibody (ab63557)
Close sc-514368|sc-365058|

Recommended applications: ELISA, WB, IHC

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-ZC3HC1 Antibody

Catalogue No.

CSB-PA801246ESR2HU

Reactivity

Human, Mouse

Immunogen

Recombinant human Nuclear-interacting partner of ALK protein (1-260AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

55 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:51530( Human), Entrez Gene:232679( Mouse), Entrez Gene:296957( Rat), SwissProt:Q86WB0( Human), SwissProt:Q80YV2( Mouse), Unigene:194157( Human), Unigene:29780( Mouse), Unigene:474686( Mouse)

Protein function

Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events. .

Protein tissue specificity

Widely expressed. Highly expressed in heart, skeletal muscle and testis. Expressed in brain, placenta, lung, kidney, liver, pancreas, spleen, thymus, prostate, ovary small intestine and colon. Weakly or not expressed in leukocytes. .

Protein sequence and domain

The F-box-like region is required for the interaction with SKP1.

Protein post-translational modifications

Phosphorylated. Phosphorylated on Ser residues at G2/M phase, but not during S and G0 phases. May also be weakly phosphorylated on Tyr residues. Ser-354 phosphorylation, a major site during the course of cell-cycle-dedendent phosphorylation, results in its dissociation from the SCF(NIPA) complex, thereby preventing CCNB1 degradation leading to mitotic entry. .

Protein cellular localization

Nucleus .

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!