Anti-ZFPM2 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-ZFPM2 Antibody (CSB-PA855487DSR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Zinc finger protein ZFPM2 Antibody,Friend of GATA protein 2 Antibody,FOG-2 Antibody,Friend of GATA 2 Antibody,hFOG-2 Antibody,Zinc finger protein 89B Antibody,Zinc finger protein multitype 2 Antibody,ZFPM2 Antibody,FOG2 Antibody,ZNF89B Antibody

More alternative names for the antibody
FOG-2 antibody|FOG2_HUMAN antibody|Friend of GATA 2 antibody|Friend of GATA protein 2 antibody|Friend of GATA2 antibody|hFOG-2 antibody|ZFPM2 antibody|Zinc finger protein 89B antibody|Zinc finger protein M2 antibody|Zinc finger protein multitype 2 antibody|Zinc finger protein ZFPM2 antibody
Anti-FOG2 antibody (ab123879)
Close sc-398011|sc-9365|sc-9364|sc-10755|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-ZFPM2 Antibody

Catalogue No.

CSB-PA855487DSR1HU

Reactivity

Human

Immunogen

Recombinant human Zinc finger protein ZFPM2 protein (982-1151AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

128 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:23414( Human), Omim:603693( Human), SwissProt:Q8WW38( Human), Unigene:431009( Human)

Protein function

Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2 (By similarity). .

Protein tissue specificity

Widely expressed at low level. .

Involvement in disease

Tetralogy of Fallot (TOF) [MIM:187500]: A congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing cyanosis. . Note=The disease may be caused by mutations affecting the gene represented in this entry.; Diaphragmatic hernia 3 (DIH3) [MIM:610187]: Form of congenital diaphragmatic hernia (CDH). CDH refers to a group of congenital defects in the structural integrity of the diaphragm associated with often lethal pulmonary hypoplasia and pulmonary hypertension. . Note=The disease is caused by mutations affecting the gene represented in this entry.; 46,XY sex reversal 9 (SRXY9) [MIM:616067]: A disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females or have ambiguous external genitalia. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Conotruncal heart malformations (CTHM) [MIM:217095]: A group of congenital heart defects involving the outflow tracts. Examples include truncus arteriosus communis, double-outlet right ventricle and transposition of great arteries. Truncus arteriosus communis is characterized by a single outflow tract instead of a separate aorta and pulmonary artery. In transposition of the great arteries, the aorta arises from the right ventricle and the pulmonary artery from the left ventricle. In double outlet of the right ventricle, both the pulmonary artery and aorta arise from the right ventricle. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the FOG (Friend of GATA) family. The CCHC FOG-type zinc fingers 1, 2, 3 and 5 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC FOG-type zinc finger is essential for the interaction with GATA-type zinc fingers (By similarity).

Protein post-translational modifications

Sumoylation reduces transcriptional repression activity. .

Protein cellular localization

Nucleus .

Research area

All research areas>Transcription Regulators>FOG
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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