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Rabbit Anti-ZIC3 Antibody (CSB-PA026486ESR2HU)
Supplier: CUSABIO BIOTECH CO.
Zinc finger protein ZIC 3 Antibody,Zinc finger protein 203 Antibody,Zinc finger protein of the cerebellum 3 Antibody,ZIC3 Antibody,ZNF203 AntibodyMore alternative names for the antibody
Heterotaxy 1 antibody|HTX antibody|HTX1 antibody|ZIC 3 antibody|Zic family member 3 (odd paired Drosophila homolog heterotaxy 1) antibody|Zic family member 3 antibody|Zic3 antibody|ZIC3_HUMAN antibody|Zinc finger protein 203 antibody|Zinc finger protein of the cerebellum 3 antibody|Zinc finger protein ZIC 3 (Zinc finger protein of the cerebellum 3) antibody|Zinc finger protein ZIC 3 antibody|ZNF203 antibody
Anti-ZIC3 antibody (ab189969)
Anti-ZIC3 antibody (ab189969)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Zinc finger protein ZIC 3 protein (1-240AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7547" target="_blank">Entrez Gene:7547( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=22773" target="_blank">Entrez Gene:22773( Mouse)</a>, <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=367944" target="_blank">Entrez Gene:367944( Rat)</a>, <a href="http://www.ncbi.nlm.nih.gov/omim/300265" target="_blank">Omim:300265( Human)</a>, <a href="http://www.uniprot.org/uniprot/O60481" target="_blank">SwissProt:O60481( Human)</a>, <a href="http://www.uniprot.org/uniprot/Q62521" target="_blank">SwissProt:Q62521( Mouse)</a>, <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=111227" target="_blank">Unigene:111227( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mm&CID=255890" target="_blank">Unigene:255890( Mouse)</a>
|Protein function|| |
Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. .
|Involvement in disease|| |
Heterotaxy, visceral, 1, X-linked (HTX1) [MIM:306955]: A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. Visceral heterotaxy or situs ambiguus results in randomization of the placement of visceral organs, including the heart, lungs, liver, spleen, and stomach. The organs are oriented randomly with respect to the left-right axis and with respect to one another. It can been associated with variety of congenital defects including cardiac malformations. . Note=The disease is caused by mutations affecting the gene represented in this entry.; VACTERL association X-linked with or without hydrocephalus (VACTERLX) [MIM:314390]: A syndrome characterized by a non-random association of congenital defects. Affected individuals manifest vertebral anomalies (V), anal atresia (A), cardiac malformations (C), tracheoesophageal fistula (TE), renal anomalies (R) such as urethral atresia with hydronephrosis, and limb anomalies (L) such as hexadactyly, humeral hypoplasia, radial aplasia, and proximally placed thumb. Some patients may have hydrocephalus. Some cases of VACTERL-H are associated with increased chromosome breakage and rearrangement. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Congenital heart defects, multiple types, 1, X-linked (CHTD1) [MIM:306955]: A disorder characterized by congenital developmental abnormalities involving structures of the heart. Common defects include transposition of the great arteries, aortic stenosis, atrial septal defect, ventricular septal defect, pulmonic stenosis, and patent ductus arteriosus. The etiology of CHTD is complex, with contributions from environmental exposure, chromosomal abnormalities, and gene defects. Some patients with CHTD also have cardiac arrhythmias, which may be due to the anatomic defect itself or to surgical interventions. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the GLI C2H2-type zinc-finger protein family. The C2H2-type 3, 4 and 5 zinc finger domains are necessary for transcription activation.
|Protein cellular localization|| |
Nucleus. Cytoplasm . Note=Localizes in the cytoplasm in presence of MDFIC overexpression (By similarity). Translocation to the nucleus requires KPNA1 or KPNA6. .
|Research area|| |
<a href="https://antibodyplus.com/research-areas/">All research areas</a>><a href="https://antibodyplus.com/Transcription-Regulators/">Transcription Regulators</a>><a href="https://antibodyplus.com/product-tag/Zic/">Zic</a><br><a href="https://antibodyplus.com/product-tag/Transcription-Regulators/"> (View all antibody categories related to Transcription Regulators)</a>
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|Product type|| |
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