Human ACPA ELISA Kit (ARG80351)

$699.00

Size: 96 wells
Conjugation:
Supplier: Arigo Biolaboratories

Overview


Supplier : Arigo Biolaboratories

 Production type ELISA Kits
Tested Reactivity Human
Tested Application ELISA
Specificity
Target Name ACPA
Conjugation
Conjugation Note
Sensitivity 1 U/ml
Detection Range
Sample Type Serum, Plasma
Sample Volume 10 ul
Precision

CV: <10%

Full Name proteinase 3
Alternate Names Check alternative names for the Human ACPA ELISA Kit

Expand

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Application Instructions

 

Assay Time 30, 15, 15, 5 min (RT)


Properties

 

Form 96 wells
Storage instruction Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components or simply ask Antibodyplus for ELISA troublesooting.
Note Antibodyplus and Arigo provide the most validated ELISA kits for researchers. For laboratory research only, not for drug, diagnostic or other use.
User’s manual of Human ACPA ELISA Kit  Download
size

96 wells

Cat No.

ARG80351

Sensitivity

1 U/ml

Sample type

Serum, Plasma

Sample Volume

10 ul

Precision

CV: <10%

Target name

ACPA

Assay time

30, 15, 15, 5 min (RT)

Store at

4 Celcius degree

Storage instruction

Store the kit at 2-8 Celcius degree. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components.

Background

Rheumatoid arthritis (RA) is one of the most common autoimmune diseases. The main characteristic of RA is joint inflammation that results in joint damage and loss of function. An early diagnosis of RA and an immediate beginning of an appropriate treatment is important to prevent a complete joint dam- age. RA is diagnosed primarily on clinical manifestations and serological support has, up to now, been mainly restricted to the determination of autoantibodies against rheumatoid factor (RF). RF is a sensi- tive serological marker for RA with a moderate specificity of about 70%. In several studies it has been demonstrated that the determination of antibodies against citrullinated arginine residues in filament proteins occurs in RF negative patients. Citrullination is a peptidylarginine deiminase (PAD) catalyzed process in which the amino acid arginine (Arg) is modified to citrullin. During this conversion, the posi- tively charged NH2-group is hydrolyzed to an oxygen group. ACPA ELISA shows both a high specificity and a high sensitivity for auto-antibodies against citrulli- nated vimentin. Vimentin is an omnipresent citrullinated protein which was observed in the rheumatoid synovial tissue of RA patients. There are recent findings of secernation and modification of vimentin by macrophages depending on pro-inflammatory signals. The titer of antibodies against vimentin in RA patients strongly correlates with the disease activity score (DAS).

Database link

All research areas>Lymphocyte Signaling>PR3
(View all antibody categories related to Lymphocyte Signaling)

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