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Supplier : Arigo Biolaboratories
|Production type||ELISA Kits|
|Sample Type||Serum, Plasma|
|Sample Volume||10 ul|
|Full Name||proteinase 3|
|Alternate Names||Check alternative names for the Human ACPA ELISA Kit Expand
ACPA Elisa kits|AGP 7 Elisa kits|AGP7 Elisa kits|AGP7 serine proteinase Elisa kits|Azurophil Granule Protein 7 Elisa kits|C ANCA Elisa kits|C ANCA antigen Elisa kits|C-ANCA antigen Elisa kits|CANCA Elisa kits|EC 188.8.131.52 Elisa kits|Leukocyte proteinase 3 Elisa kits|MBN Elisa kits|MBT Elisa kits|MBT WEGENER AUTOANTIGEN Elisa kits|Myeloblastin Elisa kits|Neutrophil proteinase 4 Elisa kits|NP 4 Elisa kits|NP-4 Elisa kits|NP4 Elisa kits|P29 Elisa kits|PR 3 Elisa kits|PR-3 Elisa kits|PR3 Elisa kits|Proteinase 3 Elisa kits|Proteinase3 Elisa kits|PRTN 3 Elisa kits|Prtn3 Elisa kits|PRTN3_HUMAN Elisa kits|Serine proteinase neutrophil Wegener granulomatosis autoantigen Elisa kits|Serine proteinase, neutrophil Elisa kits|Wegener autoantigen Elisa kits|Wegener granulomatosis autoantigen Elisa kits
|Assay Time||30, 15, 15, 5 min (RT)|
|Storage instruction||Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components or simply ask Antibodyplus for ELISA troublesooting.|
|Note||Antibodyplus and Arigo provide the most validated ELISA kits for researchers. For laboratory research only, not for drug, diagnostic or other use.|
|User’s manual of Human ACPA ELISA Kit||Download|
|Cat No.|| |
|Sample type|| |
|Sample Volume|| |
|Target name|| |
|Assay time|| |
30, 15, 15, 5 min (RT)
|Store at|| |
4 Celcius degree
|Storage instruction|| |
Store the kit at 2-8 Celcius degree. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components.
Rheumatoid arthritis (RA) is one of the most common autoimmune diseases. The main characteristic of RA is joint inflammation that results in joint damage and loss of function. An early diagnosis of RA and an immediate beginning of an appropriate treatment is important to prevent a complete joint dam- age. RA is diagnosed primarily on clinical manifestations and serological support has, up to now, been mainly restricted to the determination of autoantibodies against rheumatoid factor (RF). RF is a sensi- tive serological marker for RA with a moderate specificity of about 70%. In several studies it has been demonstrated that the determination of antibodies against citrullinated arginine residues in filament proteins occurs in RF negative patients. Citrullination is a peptidylarginine deiminase (PAD) catalyzed process in which the amino acid arginine (Arg) is modified to citrullin. During this conversion, the posi- tively charged NH2-group is hydrolyzed to an oxygen group. ACPA ELISA shows both a high specificity and a high sensitivity for auto-antibodies against citrulli- nated vimentin. Vimentin is an omnipresent citrullinated protein which was observed in the rheumatoid synovial tissue of RA patients. There are recent findings of secernation and modification of vimentin by macrophages depending on pro-inflammatory signals. The titer of antibodies against vimentin in RA patients strongly correlates with the disease activity score (DAS).
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