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Supplier : Arigo Biolaboratories
|Production type||ELISA Kits|
|Specificity||No significant cross-reactivity or interference with BD-1 (36 aa), BD-1 (47 aa), BD-2, BD-3.|
|Target Name||Human BD-4 / beta Defensin-4|
|Conjugation Note||Substrate: TMB and read at 450 nm|
|Sample Type||Serum, Plasma, Cell culture supernatants|
|Sample Volume||100 ul|
|Full Name||defensin, beta 104A|
|Alternate Names||Check alternative names for the Human BD-4 / beta Defensin-4 ELISA kit Expand
BD 4 Elisa kits|BD-4 Elisa kits|BD4 Elisa kits|beta 104 Elisa kits|Beta defensin 4 Elisa kits|Beta-defensin 104 Elisa kits|Beta-defensin 4 Elisa kits|D104A_HUMAN Elisa kits|DEFB-4 Elisa kits|DEFB104B Elisa kits|Defensin Elisa kits|Defensin beta 104 Elisa kits|Defensin beta 4 precursor Elisa kits|hBD 4 Elisa kits|hBD-4 Elisa kits|hBD4 Elisa kits
|Assay Time||4 hours|
|Storage instruction||Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components or simply ask Antibodyplus for ELISA troublesooting.|
|Note||Antibodyplus and Arigo provide the most validated ELISA kits for researchers. For laboratory research only, not for drug, diagnostic or other use.|
|User’s manual of Human BD-4 / beta Defensin-4 ELISA kit||Download|
|Cat No.|| |
|Conjugation note|| |
Substrate: TMB and read at 450 nm
|Sample type|| |
Serum, Plasma, Cell culture supernatants
|Sample Volume|| |
|Target name|| |
Human BD-4 / beta Defensin-4
|Assay time|| |
|Store at|| |
4 Celcius degree
|Storage instruction|| |
Store the kit at 2-8 Celcius degree. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components.
Defensins are 2-6 kDa, cationic, microbicidal peptides active against many Gram-negative and Gram-positive bacteria, fungi, and enveloped viruses [PMID: 8528769], containing three pairs of intramolecular disulphide bonds. On the basis of their size and pattern of disulphide bonding, mammalian defensins are classified into alpha, beta and theta categories. Every mammalian species explored thus far has beta-defensins. In cows, as many as 13 beta-defensins exist in neutrophils. However, in other species, beta-defensins are more often produced by epithelial cells lining various organs (e.g. the epidermis, bronchial tree and genitourinary tract). Defensins are produced constitutively and/or in response to microbial products or proinflammatory cytokines. Some defensins are also called corticostatins (CS) because they inhibit corticotropin-stimulated corticosteroid production. The mechanism(s) by which microorganisms are killed and/or inactivated by defensins is not understood completely. However, it is generally believed that killing is a consequence of disruption of the microbial membrane. The polar topology of defensins, with spatially separated charged and hydrophobic regions, allows them to insert themselves into the phospholipid membranes so that their hydrophobic regions are buried within the lipid membrane interior and their charged (mostly cationic) regions interact with anionic phospholipid head groups and water. Subsequently, some defensins can aggregate to form `channel-like’ pores; others might bind to and cover the microbial membrane in a `carpet-like’ manner. The net outcome is the disruption of membrane integrity and function, which ultimately leads to the lysis of microorganisms. Some defensins are synthesised as propeptides which may be relevant to this process. [provide by Interpro: IPR006080]
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