Human Calcitonin ELISA Kit (ARG80776)

$749.00

Size: 96 wells
Conjugation: HRP
Supplier: Arigo Biolaboratories

Overview


Supplier : Arigo Biolaboratories

 Production type ELISA Kits
Tested Reactivity Human
Tested Application ELISA
Specificity
Target Name Calcitonin
Conjugation HRP
Conjugation Note Substrate: TMB and read at 450/490 nm
Sensitivity 1.3 pg/ml
Detection Range
Sample Type serum, plasma
Sample Volume 50 ul
Precision

CV: <10%

Full Name calcitonin-related polypeptide alpha
Alternate Names Check alternative names for the Human Calcitonin ELISA Kit

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Application Instructions

 

Assay Time 18 h (2-8 Celcius degree), 30 min (RT)


Properties

 

Form 96 wells
Storage instruction Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components or simply ask Antibodyplus for ELISA troublesooting.
Note Antibodyplus and Arigo provide the most validated ELISA kits for researchers. For laboratory research only, not for drug, diagnostic or other use.
User’s manual of Human Calcitonin ELISA Kit  Download
size

96 wells

Cat No.

ARG80776

Conjugation note

Substrate: TMB and read at 450/490 nm

Sensitivity

1.3 pg/ml

Sample type

serum, plasma

Sample Volume

50 ul

Precision

CV: <10%

Target name

Calcitonin

Assay time

18 h (2-8 Celcius degree), 30 min (RT)

Store at

4 Celcius degree

Storage instruction

Store the kit at 2-8 Celcius degree. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components.

Background

Calcitonin (CT) is a 32 amino acid peptide hormone secreted by the para-follicular C-cells of the thyroid gland under serum calcium control. After acute administration, this peptide acts as a potent hypocalcemic and hypophosphatemic hormone by increasing renal calcium clearance and reducing bone resorption. However, its precise physiological role in bone metabolism is not yet fully understood. Various forms of CT may be detected in blood samples, including a CT monomer, an oxidized monomer, a dimer, higher molecular weight forms, and possibly precursor of CT. The concentrations of these peptides vary with clinical status, renal function and tissular origin of CT (normal or ectopic production). Medullar thyroid carcinoma (MTC) is a malignant tumor, developed from the C-cells, secreting calcitonin in large excess. This disease occurs either as a sporadic (80%) or a familial (20%) form, which is transmitted as an autosomal dominant gene or as a component of multiple endocrine neoplasia (IIb). Moderate hypercalcitoninemia is also observed in pregnancy, pernicious anaemia, renal failure and during the neonatal period. Preferably, monomer form of CT is detected in this assay. The measurement of CT is used for: ¡¤ Diagnosis of medullary thyroid carcinoma (MTC), ¡¤ Follow up of malignant tumors, to check the success of surgery and to monitor for recurrence, ¡¤ Diagnosis of the preclinical cases of the familial forms of MTC (MEN II or Sipple syndrome) by the use of stimulation tests (calcium or pentagastrin), ¡¤ Study of the pathophysiology of the calcium-phosphate and bone metabolism.

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