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Supplier : Arigo Biolaboratories
|Production type||ELISA Kits|
|Target Name||Human Factor XII|
|Conjugation Note||TMB substrate is used for color development at 450 nm.|
|Detection Range||0.1 – 100 ng/ml|
|Full Name||coagulation factor XII (Hageman factor)|
|Alternate Names||Check alternative names for the Human Factor XII (total) ELISA Kit Expand
Coagulation factor XII Elisa kits|Coagulation factor XIIa heavy chain Elisa kits|F12 Elisa kits|HAE3 Elisa kits|HAEX Elisa kits|HAF Elisa kits|Hageman factor Elisa kits
|Storage instruction||Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components or simply ask Antibodyplus for ELISA troublesooting.|
|Note||Antibodyplus and Arigo provide the most validated ELISA kits for researchers. For laboratory research only, not for drug, diagnostic or other use.|
|User’s manual of Human Factor XII (total) ELISA Kit||Download|
|Cat No.|| |
|Conjugation note|| |
TMB substrate is used for color development at 450 nm.
|Detection range|| |
0.1 – 100 ng/ml
|Sample type|| |
|Target name|| |
Human Factor XII
|Store at|| |
4 Celcius degree
|Storage instruction|| |
Store the kit at 2-8 Celcius degree. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components.
This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq, Jul 2008]
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