Human IA2 autoantibody ELISA Kit (ARG80781)

$899.00

Size: 96 wells
Conjugation: HRP
Supplier: Arigo Biolaboratories

Overview


Supplier : Arigo Biolaboratories

 Production type ELISA Kits
Tested Reactivity Human
Tested Application ELISA
Specificity
Target Name IA2 autoantibody
Conjugation HRP
Conjugation Note Substrate: TMB and read at 450 nm
Sensitivity 1.25 U/ml
Detection Range
Sample Type serum
Sample Volume 50 ul
Precision

CV: <10%

Full Name IA2 autoantibody (Islet Antigen 2 autoantibody)
Alternate Names Check alternative names for the Human IA2 autoantibody ELISA Kit

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Application Instructions

 

Assay Time 16-20 h, 1 h (2-8 Celcius degree), 20 min (RT/shaker), 20 min (RT/dark)


Properties

 

Form 96 wells
Storage instruction Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components or simply ask Antibodyplus for ELISA troublesooting.
Note Antibodyplus and Arigo provide the most validated ELISA kits for researchers. For laboratory research only, not for drug, diagnostic or other use.
User’s manual of Human IA2 autoantibody ELISA Kit  Download
size

96 wells

Cat No.

ARG80781

Conjugation note

Substrate: TMB and read at 450 nm

Sensitivity

1.25 U/ml

Sample type

serum

Sample Volume

50 ul

Precision

CV: <10%

Target name

IA2 autoantibody

Assay time

16-20 h, 1 h (2-8 Celcius degree), 20 min (RT/shaker), 20 min (RT/dark)

Store at

4 Celcius degree

Storage instruction

Store the kit at 2-8 Celcius degree. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components.

Background

Islet cell autoantibodies have been known to be associated with type 1 diabetes mellitus for 36 years. In recent years, several autoantigens against which islet antibodies are directed have been identified. These include the tyrosine phosphatase-related islet antigen 2 (IA-2), glutamic acid decarboxylase 65, the zinc transporter ZnT8, and insulin. One or more of these autoantibodies are detected in 96% of patients with type 1 diabetes, and are detectable before clinical onset, as well as in symptomatic individuals. A serological study of 50 type 1 diabetics and 50 control subjects conducted simultaneously across 43 laboratories in 16 countries demonstrated a median sensitivity of 57% and a median specificity of 99% for IA-2 antibody in type 1 diabetes. Prospective studies in relatives of patients with type 1 diabetes have shown that development of 1 or more islet autoantibodies (including IA-2 antibody) provides an early marker of progression to type 1 diabetes. Autoantibody profiles identifying patients destined to develop type 1 diabetes are usually detectable before age 3. In 1 study of relatives seropositive for IA-2 antibody, the risk of developing type 1 diabetes within 5 years was 65.3%. Some patients with type 1 diabetes are initially diagnosed as having type 2 diabetes because of symptom onset in adulthood, societal obesity, and initial insulin-independence. These patients with “latent autoimmune diabetes in adulthood” may be distinguished from those patients with type 2 diabetes by detection of 1 or more islet autoantibodies (including IA-2). [From Mayo Medical Laboratories]

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