Human IgG4 Screen Nutritional 88 ELISA Kit (ARG80822)

$599.00

Size: 96 wells
Conjugation: AP
Supplier: Arigo Biolaboratories

Overview


Supplier : Arigo Biolaboratories

 Production type ELISA Kits
Tested Reactivity Human
Tested Application ELISA
Specificity
Target Name IgG4 Screen Nutritional 88
Conjugation AP
Conjugation Note Substrate: PNPP and read at 405 nm
Sensitivity depending on allergen
Detection Range
Sample Type serum, plasma
Sample Volume 100 ul
Precision

CV: <10%

Full Name IgG4 Screen Nutritional 88
Alternate Names Check alternative names for the Human IgG4 Screen Nutritional 88 ELISA Kit

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Application Instructions

 

Assay Time 1 h, 30 min (37 Celcius degree), 1 h (37 Celcius degree/dark)


Properties

 

Form 96 wells
Storage instruction Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components or simply ask Antibodyplus for ELISA troublesooting.
Note Antibodyplus and Arigo provide the most validated ELISA kits for researchers. For laboratory research only, not for drug, diagnostic or other use.
User’s manual of Human IgG4 Screen Nutritional 88 ELISA Kit  Download
size

96 wells

Cat No.

ARG80822

Conjugation note

Substrate: PNPP and read at 405 nm

Sensitivity

depending on allergen

Sample type

serum, plasma

Sample Volume

100 ul

Precision

CV: <10%

Target name

IgG4 Screen Nutritional 88

Assay time

1 h, 30 min (37 Celcius degree), 1 h (37 Celcius degree/dark)

Store at

4 Celcius degree

Storage instruction

Store the kit at 2-8 Celcius degree. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components.

Background

Incompatibility reactions against food may cause various symptoms in the human organism and this disturbance is manifested in the immune system by the formation of specific IgE, IgG or IgG4 antibodies. Statistics show that 60% of the population suffer from intolerances against at least one foodstuff, which may cause clinical symptoms or enhance them. Hints may be various and reach from skin irritations over digestive disorders up to migraine. With the diagnostic findings of unspecific discomfort, allergies or intolerances against food should be clarified. The theoretical basis for the determination of specific IgG or IgG4 for the diagnosis of food intolerances depends on the observation that some subclasses of IgG (mainly IgG4) are connected to the in vitro degranulation of basophilic cells and mastocytes and the activation of the complement cascade. It was also observed that high concentrations of circulating IgG were measured in atopic persons. Already early surveys showed that in persons with inflammatory reactions against food IgG but not IgE was detected. Significantly enhanced IgG and IgG4 titers were also found in patients with food intolerances. Skin tests are relatively poorly correlated to food allergies and are only significant in the presence of IgE related reactions. As additional diagnostic tools provocation and elimination diets are applied. These methods depend strongly on the motivation and compliance of the patient. Due to these constraints nowadays serological determinations of antibodies against various food panels are applied increasingly. The two reactions related with the immune system differ insofar as the IgE associated food allergy occurs within the next hour following the food intake, while IgG/IgG4 intolerances show a delayed reaction of 24 to 120 hours and persistent symptoms may arise.

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