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Supplier : Arigo Biolaboratories
|Production type||ELISA Kits|
|Target Name||LC1 antibody|
|Sample Type||Serum, Plasma|
|Sample Volume||10 ul|
|Alternate Names||Check alternative names for the Human LC1 antibody ELISA Kit Expand|
|Assay Time||30, 30, 30 min (RT)|
|Storage instruction||Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components or simply ask Antibodyplus for ELISA troublesooting.|
|Note||Antibodyplus and Arigo provide the most validated ELISA kits for researchers. For laboratory research only, not for drug, diagnostic or other use.|
|User’s manual of Human LC1 antibody ELISA Kit||Download|
|Cat No.|| |
|Sample type|| |
|Sample Volume|| |
|Target name|| |
|Assay time|| |
30, 30, 30 min (RT)
|Store at|| |
4 Celcius degree
|Storage instruction|| |
Store the kit at 2-8 Celcius degree. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components.
Anti-LC-1 is used for the quantitative determination of IgG antibodies to formiminotransferase-cyclodeaminase in human serum or plasma for the diagnosis of autoimmune hepatitis (AIH). The group of primary autoimmune liver disease (PAL) comprises AIH, primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). The clinical picture of PAL is in most cases not different from other chronic liver diseases. About 15% of all cases with chronic liver diseases show an autoimmune pathogenesis. Therefore, after exclusion of infectious etiology especially by viruses, the determination of different autoantibodies is recommended. Patients suffering from AIH show a variety of autoantibodies. Due to the appearance of different antibody specificities classification of AIH into different subgroups is discussed. Type I is characterized by the occurrence of antinuclear antibodies (ANA) and antibodies to smooth muscles (ASMA). ASMA recognize antigenic structure formed by polymeric f-Actin. For type II a high prevalence of antibodies to liver and kidney microsomal antigens (LKM) has been described. LKM1 antibodies recognize epitopes of cytochrome P450 IID6, a 50 kDa cytoplasmic protein found in hepatocytes and proximal tubular kidney cells. LC-1 antibodies are specific for type II hepatitis, too. The respective antigen is formiminotransferase-cyclodeaminase (FTCD) a 58 kDa metabolic enzyme located in the cytosol of liver cells. FTCD is a bifunctional protein that comprises distinct globular domains of formiminotransferase and cyclodeaminase combined by a short linker. Patients with type III autoimmune hepatitis exhibit antibodies to the soluble liver antigen (SLA). This type III is not yet fully accepted as independent subgroup for autoimmune hepatitis by the ¡°International Hepatitis Group¡±. In 10% of AIH cases LC-1 autoantibodies are the only liver-related circulating autoantibodies what underlines the importance of this serological parameter for the differential diagnosis of AIH. Czaja AL. Natural history, clinical features and treatment of autoimmune hepatitis. Semin Liver Dis (1987) 4: 1 ¨C 12 Johnson PJ, McFarlane IA. Meeting Report: International Autoimmune Hepatitis Group. Hepatology (1993) 18: 998 ¨C 1005 Lapierre P, Hajoui O, Homberg JC, Alvarez F: Formiminotransferase cyclodeaminase is an organ-specific autoantigen recognized by sera of patients with autoimmune hepatitis. Gastroenterol (1999) 116: 643-649
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