Human Thyroid Peroxidase (TPO) autoantibodies ELISA Kit (ARG80892)

$599.00

Size: 96 wells
Conjugation: HRP
Supplier: Arigo Biolaboratories

Overview


Supplier : Arigo Biolaboratories

 Production type ELISA Kits
Tested Reactivity Human
Tested Application ELISA
Specificity
Target Name Thyroid Peroxidase (TPO) autoantibody
Conjugation HRP
Conjugation Note Substrate: TMB and read at 450 nm
Sensitivity 5 IU/ml
Detection Range
Sample Type serum, plasma 1:100 diluted
Sample Volume 10 ul
Precision

CV: <10%

Full Name Thyreoidal Peroxidase Autoantibodies (TPO-Ab)
Alternate Names Check alternative names for the Human Thyroid Peroxidase (TPO) autoantibodies ELISA Kit

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Application Instructions

 

Assay Time 30, 15, 15, 5 min (RT)


Properties

 

Form 96 wells
Storage instruction Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components or simply ask Antibodyplus for ELISA troublesooting.
Note Antibodyplus and Arigo provide the most validated ELISA kits for researchers. For laboratory research only, not for drug, diagnostic or other use.
User’s manual of Human Thyroid Peroxidase (TPO) autoantibodies ELISA Kit  Download
size

96 wells

Cat No.

ARG80892

Conjugation note

Substrate: TMB and read at 450 nm

Sensitivity

5 IU/ml

Sample type

serum, plasma 1:100 diluted

Sample Volume

10 ul

Precision

CV: <10%

Target name

Thyroid Peroxidase (TPO) autoantibody

Assay time

30, 15, 15, 5 min (RT)

Store at

4 Celcius degree

Storage instruction

Store the kit at 2-8 Celcius degree. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components.

Background

Thyroid disorders are the most prevalent of all autoimmune diseases. Thyroid autoimmune diseases are associated with the occurrence of differentiated autoantibodies and are thought to be related to a genetical pre-disposition. These autoantibodies are directed against membrane- located and/or extracellular antigens of the thyroid cells: Human Thyroglobulin (hTG), a water soluble glycoprotein with a molecular weight of approx. 660.000 Dalton, is the principal constituent of the thyroidal colloid sharing about 75 % of its mass. Synthesis of the thyroid hormones T3 and T4 is based on the oxidative iodination of tyrosine residues of the thyroglobulin molecule. Within the cell thyroglobulin is transported by the microsomes. Together with the secretion of T3 and T4 also small amounts of hTG are liberated into circulation. The microsomal antigen of the thyroid is an integral membrane protein of the microsomes. It has been characterised as the enzyme Thyroid Peroxidase (TPO) with a molecular weight of nearly 110.000 Dalton. The TSH-Receptor is a regulatory protein embedded into the thyroid cell membrane effecting synthesis and release of the thyroid hormones as well as cellular growth. The so-called Colloid-Antigen 2 CA2.

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