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Mouse Monoclonal 4E-BP1 antibody [4B6G10] (STJ97804)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
Click or hover above images to see image description for 4E-BP1 Monoclonal Antibody.
Check alternative names for the antibodyExpand
EIF4EBP1 antibody,|4E-BP1 antibody|4EBP1 antibody|4EBP1_HUMAN antibody|BP 1 antibody|eIF4E binding protein 1 antibody|eIF4E-binding protein 1 antibody|Eif4ebp1 antibody|Eukaryotic translation initiation factor 4E-binding protein 1 antibody|PHAS-I antibody|PHASI antibody|Phosphorylated heat- and acid-stable protein regulated by insulin 1 antibody|Anti-eIF4EBP1 antibody (ab2606)
SCBT cat No: sc-81149|sc-6024|sc-514073|sc-6025|sc-9977|sc-6936|sc-74397|sc-134232|sc-81175|sc-393788|sc-13454|sc-514810|sc-13453|sc-134233|
4E-BP1 Monoclonal Antibody
|Catalogue No.|| |
4E-BP1 Monoclonal Antibody detects endogenous levels of 4E-BP1 protein.
Purified recombinant fragment of 4E-BP1 expressed in E Coli
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
4E-BP1 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
4E-BP1 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Eukaryotic translation initiation factor 4E-binding protein 1 antibody, 4E-BP1 antibody, eIF4E-binding protein 1 antibody, Phosphorylated heat- and acid-stable protein regulated by insulin 1 antibody, PHAS-I antibody
|Protein names|| |
Eukaryotic translation initiation factor 4E-binding protein 1 , 4E-BP1 , eIF4E-binding protein 1 , Phosphorylated heat- and acid-stable protein regulated by insulin 1 , PHAS-I
|Protein function|| |
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
|Protein sequence and domain|| |
The TOS motif mediates interaction with RPTOR, leading to promote phosphorylation by mTORC1 complex. / Belongs to the eIF4E-binding protein family.
|Protein post-translational modifications|| |
Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylation at Thr-37, Thr-46, Ser-65 and Thr-70, corresponding to the hyperphosphorylated form, is regulated by mTORC1 and abolishes binding to EIF4E. / Ubiquitinated: when eIF4E levels are low, hypophosphorylated form is ubiquitinated by the BCR(KLHL25) complex, leading to its degradation and serving as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. Not ubiquitinated when hyperphosphorylated (at Thr-37, Thr-46, Ser-65 and Thr-70) or associated with eIF4E.
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St John’s Laboratory Ltd.
|Product type|| |
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