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Mouse Monoclonal AAT antibody [2B12] (STJ97807)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
SERPINA1 antibody, AAT antibody, PI antibody, PRO0684 antibody, PRO2209 antibody,|A1A antibody|A1AT antibody|A1AT_HUMAN antibody|AAT antibody|Alpha 1 antiproteinase antibody|Alpha 1 antitrypsin antibody|Alpha 1 antitrypsin null antibody|Alpha 1 protease inhibitor antibody|Alpha-1 protease inhibitor antibody|Alpha-1-antiproteinase antibody|alpha1 proteinase inhibitor antibody|Alpha1AT antibody|Dom1 antibody|PI antibody|PI1 antibody|PRO2275 antibody|Serine (or cysteine) proteinase inhibitor clade A member 1 antibody|Serine protease inhibitor 1-1 antibody|Serine protease inhibitor A1a antibody|Serpin A1 antibody|Serpin A1a antibody|Serpin peptidase inhibitor clade A member 1 antibody|Serpina1 antibody|Short peptide from AAT antibody|SPAAT antibody|Spi1-1 antibody|Anti-alpha 1 Antitrypsin antibody (ab9373)
SCBT cat No: sc-73431|sc-69752|sc-66025|sc-69986|sc-130299|sc-59438|sc-31919|sc-14586|sc-30121|sc-166018|
AAT Monoclonal Antibody
|Catalogue No.|| |
AAT Monoclonal Antibody detects endogenous levels of AAT protein.
Purified recombinant fragment of human AAT expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
AAT Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
AAT Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Alpha-1-antitrypsin antibody, Alpha-1 protease inhibitor antibody, Alpha-1-antiproteinase antibody, Serpin A1 antibody
|Protein names|| |
Alpha-1-antitrypsin , Alpha-1 protease inhibitor , Alpha-1-antiproteinase , Serpin A1
|Protein function|| |
Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. / Short peptide from AAT: reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).
|Protein tissue specificity|| |
Ubiquitous. Expressed in leukocytes and plasma.
|Involvement in disease|| |
Alpha-1-antitrypsin deficiency (A1ATD) [MIM:613490]: A disorder whose most common manifestation is emphysema, which becomes evident by the third to fourth decade. A less common manifestation of the deficiency is liver disease, which occurs in children and adults, and may result in cirrhosis and liver failure. Environmental factors, particularly cigarette smoking, greatly increase the risk of emphysema at an earlier age. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable. / Belongs to the serpin family.
|Protein post-translational modifications|| |
N-glycosylated. Differential glycosylation produces a number of isoforms. N-linked glycan at Asn-107 is alternatively di-antennary, tri-antennary or tetra-antennary. The glycan at Asn-70 is di-antennary with trace amounts of tri-antennary. Glycan at Asn-271 is exclusively di-antennary. Structure of glycans at Asn-70 and Asn-271 is Hex5HexNAc4. The structure of the antennae is Neu5Ac(alpha1-6)Gal(beta1-4)GlcNAc attached to the core structure Man(alpha1-6)[Man(alpha1-3)]Man(beta1-4)GlcNAc(beta1-4)GlcNAc. Some antennae are fucosylated, which forms a Lewis-X determinant. / Proteolytic processing may yield the truncated form that ranges from Asp-30 to Lys-418.
|Protein cellular localization|| |
Secreted / Endoplasmic reticulum / Secreted > extracellular space > extracellular matrix
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St John’s Laboratory Ltd.
|Product type|| |
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