Mouse Monoclonal ACE1 antibody (STJ98458)

$379.00

Reactivity: Human, Mouse, Rat, Cow
Applications: WB
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal ACE1 antibody (STJ98458)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB

Recommended dilution: WB 1:1000-1:2000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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ACE antibody, DCP antibody, DCP1 antibody,|ACE 1 antibody|ACE antibody|ACE T antibody|ACE_HUMAN antibody|ACE1 antibody|Angiotensin converting enzyme somatic isoform antibody|Angiotensin converting enzyme testis specific isoform antibody|Angiotensin I converting enzyme 1 antibody|Angiotensin I converting enzyme antibody|Angiotensin I converting enzyme peptidyl dipeptidase A 1 antibody|angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript antibody|Angiotensin-converting enzyme antibody|Carboxycathepsin antibody|CD 143 antibody|CD143 antibody|CD143 antigen antibody|DCP 1 antibody|DCP antibody|DCP1 antibody|Dipeptidyl carboxypeptidase 1 antibody|Dipeptidyl carboxypeptidase I antibody|Kininase II antibody|MGC26566 antibody|MVCD3 antibody|Peptidase P antibody|Peptidyl dipeptidase A antibody|soluble form antibody|Testicular ECA antibody|Anti-Angiotensin Converting Enzyme 1 antibody [9B9] (ab77990)
SCBT cat No: sc-23908|sc-69994|sc-69993|sc-69991|sc-69992|sc-23909|sc-374198|sc-12187|sc-271860|sc-20791|sc-376132|sc-12184|

 

Name

ACE1 Monoclonal Antibody

Catalogue No.

STJ98458

Reactivity

Human, Mouse, Rat, Cow

Specificity

ACE1 Monoclonal Antibody detects endogenous levels of ACE1 protein.

Immunogen

Purified recombinant human ACE1 (N-terminus) protein fragments expressed in Ecoli

Host

Mouse

Applications

WB

Recommended dilution

WB 1:1000-1:2000

Clonality

Monoclonal

Conjugation

Unconjugated

Formulation

ACE1 Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

Concentration

1 mg/ml

Purification

ACE1 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Angiotensin-converting enzyme antibody, ACE antibody, Dipeptidyl carboxypeptidase I antibody, Kininase II antibody, CD antigen CD143 antibody

Database links

Human UniProt/Swiss-Prot:P12821;Mouse UniPort/Swiss-Prot: P09470;Rat UniProt/Swiss-Port: P47820;Human Entrez Gene: 1636;Mouse Entrez Gene: 11421;Rat Entrez Gene: Rn.10149

Protein names

Angiotensin-converting enzyme , ACE , Dipeptidyl carboxypeptidase I , Kininase II , CD antigen CD143

Protein function

Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. / Release of a C-terminal dipeptide, oligopeptide-, -Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II. / Zn2+ / chloride / Zn2+ / Strongly activated by chloride. Specifically inhibited by lisinopril, captopril and enalaprilat. / 2.51 mM for Hip-His-Leu

Protein tissue specificity

Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate. Isoform Testis-specific is expressed in spermatocytes and adult testis.

Involvement in disease

Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. . Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.; Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). . Note: The disease is caused by mutations affecting the gene represented in this entry.; Microvascular complications of diabetes 3 (MVCD3) [MIM:612624]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. . Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.; Intracerebral hemorrhage (ICH) [MIM:614519]: A pathological condition characterized by bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma. Intracerebral bleeding is a common cause of stroke. . Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the peptidase M2 family.

Protein post-translational modifications

Phosphorylated by CK2 on Ser-1299; which allows membrane retention.

Protein cellular localization

Secreted / Cell membrane; Single-pass type I membrane protein / Cytoplasm

Research area

All research areas>Synthesis and Degradation>ACE
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize ACE1 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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