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Mouse Monoclonal AGT antibody [1B1] (STJ97818)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
AGT antibody, SERPINA8 antibody,|Aangiotensinogen (serpin peptidase inhibitor clade A member 8) antibody|AGT antibody|AI265500 antibody|Alpha 1 antiproteinase antitrypsin antibody|Ang antibody|Ang I antibody|Ang II antibody|Ang III antibody|AngII antibody|Angiotensin I antibody|Angiotensin II antibody|Angiotensin III antibody|Angiotensin-3 antibody|Angiotensinogen (PAT) antibody|Angiotensinogen antibody|ANGT_HUMAN antibody|ANHU antibody|ANRT antibody|AT-2 antibody|AT-II antibody|Des-Asp-angiotensin II antibody|FLJ92595 antibody|FLJ97926 antibody|MGC105326 antibody|PAT antibody|Pre angiotensinogen antibody|Serine (or cysteine) proteinase inhibitor antibody|Serpin A8 antibody|Serpin peptidase inhibitor clade A member 8 antibody|SERPINA8 antibody|Anti-Angiotensinogen antibody [EPR2931] (ab108334)
SCBT cat No: sc-374511|sc-20717|sc-7419|sc-80682|
AGT Monoclonal Antibody
|Catalogue No.|| |
AGT Monoclonal Antibody detects endogenous levels of AGT protein.
Purified recombinant fragment of human AGT expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
AGT Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
AGT Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Angiotensinogen antibody, Serpin A8 antibody, -angiotensin II antibody,; Angiotensin-4 antibody, Angiotensin 3-8 antibody, Angiotensin IV antibody, Ang IV antibody,; Angiotensin 1-9; Angiotensin 1-7; Angiotensin 1-5; Angiotensin 1-4 antibody
|Protein names|| |
Angiotensinogen , Serpin A8 , -angiotensin II ,; Angiotensin-4 , Angiotensin 3-8 , Angiotensin IV , Ang IV ,; Angiotensin 1-9; Angiotensin 1-7; Angiotensin 1-5; Angiotensin 1-4
|Protein function|| |
Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. / Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. / Angiotensin-3: stimulates aldosterone release. / Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.
|Protein tissue specificity|| |
Expressed by the liver and secreted in plasma.
|Involvement in disease|| |
Essential hypertension (EHT) [MIM:145500]: A condition in which blood pressure is consistently higher than normal with no identifiable cause. . Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.; Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the serpin family.
|Protein post-translational modifications|| |
Beta-decarboxylation of Asp-34 in angiotensin-2, by mononuclear leukocytes produces alanine. The resulting peptide form, angiotensin-A, has the same affinity for the AT1 receptor as angiotensin-2, but a higher affinity for the AT2 receptor. / In response to low blood pressure, the enzyme renin/REN cleaves angiotensinogen to produce angiotensin-1. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 and can be further processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4. Angiotensin 1-7 has also been proposed to be cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin). / The disulfide bond is labile. Angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized disulfide-bonded form, which preferentially interacts with receptor-bound renin.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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