Mouse Monoclonal Anti-ATIC antibody (STJ99146)

$99.00$319.00

Reactivity: Human, Mouse, Rat
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Anti-ATIC antibody (STJ99146)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

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SCBT cat No:

Name

Anti-ATIC antibody

Catalogue No.

STJ99146

Reactivity

Human, Mouse, Rat

Specificity

Anti-ATIC antibody detects endogenous levels of ATIC and does not cross-react with related proteins.

Immunogen

Purified recombinant human ATIC protein fragments expressed in E.coli.

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Molecular weight

64kDa

Formulation

Anti-ATIC antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-ATIC antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Database links

UniProt/Swiss-Prot:P31939

Protein function

Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis. .; Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). .

Involvement in disease

AICAR transformylase/IMP cyclohydrolase deficiency (AICAR) [MIM:608688]: A neurologically devastating inborn error of purine biosynthesis. Patients excrete massive amounts of AICA-riboside in the urine and accumulate AICA-ribotide and its derivatives in erythrocytes and fibroblasts. AICAR causes profound mental retardation, epilepsy, dysmorphic features and congenital blindness. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the PurH family. The IMP cyclohydrolase activity resides in the N-terminal region.

Note

AntibodyPlus can customize Anti-ATIC antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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