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Mouse Monoclonal Anti-ATIC antibody (STJ99146)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-ATIC antibody.
Check alternative names for the antibodyExpand
SCBT cat No:
|Catalogue No.|| |
Human, Mouse, Rat
Anti-ATIC antibody detects endogenous levels of ATIC and does not cross-react with related proteins.
Purified recombinant human ATIC protein fragments expressed in E.coli.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-ATIC antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-ATIC antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Database links|| |
|Protein function|| |
Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis. .; Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). .
|Involvement in disease|| |
AICAR transformylase/IMP cyclohydrolase deficiency (AICAR) [MIM:608688]: A neurologically devastating inborn error of purine biosynthesis. Patients excrete massive amounts of AICA-riboside in the urine and accumulate AICA-ribotide and its derivatives in erythrocytes and fibroblasts. AICAR causes profound mental retardation, epilepsy, dysmorphic features and congenital blindness. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the PurH family. The IMP cyclohydrolase activity resides in the N-terminal region.
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St John’s Laboratory Ltd.
|Product type|| |
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