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Mouse Monoclonal Anti-Aurora Kinase A antibody (STJ99106)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-Aurora Kinase A antibody.
Check alternative names for the antibodyExpand
|AIK antibody|Aurora/IPL1 like kinase antibody|AURORA2 antibody|MGC34538 antibody|OTTHUMP00000031340 antibody|OTTHUMP00000031341 antibody|OTTHUMP00000031342 antibody|OTTHUMP00000031343 antibody|OTTHUMP00000031344 antibody|OTTHUMP00000031345 antibody|OTTHUMP00000166071 antibody|OTTHUMP00000166072 antibody|PPP1R47 antibody|Protein phosphatase 1, regulatory subunit 47 antibody|Serine/threonine kinase 15 antibody|Serine/threonine kinase 6 antibody|Serine/threonine-protein kinase 15 antibody|Serine/threonine-protein kinase 6 antibody|Serine/threonine-protein kinase aurora-A antibody|STK15 antibody|STK6 antibody|STK6_HUMAN antibody|STK7 antibody|Anti-Aurora A antibody [35C1] (ab13824)
SCBT cat No: sc-56881|sc-514374|sc-398814|sc-25425|sc-14318|sc-65987|sc-393357|
Anti-Aurora Kinase A antibody
|Catalogue No.|| |
Anti-Aurora Kinase A antibody detects endogenous levels of Aurora Kinase A and does not cross-react with related proteins.
Purified recombinant human Aurora Kinase A protein fragments expressed in E.coli.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-Aurora Kinase A antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-Aurora Kinase A antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
AIK antibody, Aurora/IPL1 like kinase antibody, AURORA2 antibody, MGC34538 antibody, OTTHUMP00000031340 antibody, OTTHUMP00000031341 antibody, OTTHUMP00000031342 antibody, OTTHUMP00000031343 antibody, OTTHUMP00000031344 antibody, OTTHUMP00000031345 antibody, OTTHUMP00000166071 antibody, OTTHUMP00000166072 antibody, PPP1R47 antibody, Protein phosphatase 1, regulatory subunit 47 antibody, Serine/threonine kinase 15 antibody, Serine/threonine kinase 6 antibody, Serine/threonine-protein kinase 15 antibody, Serine/threonine-protein kinase 6 antibody, Serine/threonine-protein kinase aurora-A antibody, STK15 antibody, STK6 antibody, STK6_HUMAN antibody, STK7 antibody
|Database links|| |
|Protein function|| |
Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis. .
|Protein tissue specificity|| |
Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. ; Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
Activated by phosphorylation at Thr-288; this brings about a change in the conformation of the activation segment. Phosphorylation at Thr-288 varies during the cell cycle and is highest during M phase. Autophosphorylated at Thr-288 upon TPX2 binding. Thr-288 can be phosphorylated by several kinases, including PAK and PKA. Protein phosphatase type 1 (PP1) binds AURKA and inhibits its activity by dephosphorylating Thr-288 during mitosis. Phosphorylation at Ser-342 decreases the kinase activity. PPP2CA controls degradation by dephosphorylating Ser-51 at the end of mitosis. .; Ubiquitinated by the E3 ubiquitin-protein ligase complex SCF(FBXL7) during mitosis, leading to its degradation by the proteasome. Ubiquitinated by CHFR, leading to its degradation by the proteasome (By similarity). Ubiquitinated by the anaphase-promoting complex (APC), leading to its degradation by the proteasome. .
|Protein cellular localization|| |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Note=Detected at the neurite hillock in developing neurons (By similarity). Localizes at the centrosome in mitotic cells from early prophase until telophase, but also localizes to the spindle pole MTs from prophase to anaphase (PubMed:9606188, PubMed:17229885, PubMed:21225229). Colocalized with SIRT2 at centrosome (PubMed:22014574). Moves to the midbody during both telophase and cytokinesis (PubMed:17726514). Associates with both the pericentriolar material (PCM) and centrioles (PubMed:22014574). .
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St John’s Laboratory Ltd.
|Product type|| |
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