Mouse Monoclonal Anti-Bag1 antibody (STJ99243)

$99.00$319.00

Reactivity:
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Anti-Bag1 antibody (STJ99243)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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|Bag 1 antibody|BAG family molecular chaperone regulator 1 antibody|BAG-1 antibody|BAG1 antibody|BAG1_HUMAN antibody|BCL 2 Associated Athanogene 1 antibody|BCL 2 associated athanogene antibody|BCL 2 binding athanogene 1 antibody|Bcl-2-associated athanogene 1 antibody|BCL2 associated athanogene 1 antibody|BCL2 associated athanogene antibody|Glucocorticoid receptor-associated protein RAP46 antibody|HAP1 antibody|Haptoglobin antibody|RAP 46 antibody|RAP46 antibody|Anti-Bag1 antibody [Y166] (ab32109)
SCBT cat No: sc-135844|sc-56003|sc-56004|sc-377419|sc-515535|sc-939|sc-33704|sc-376848|sc-515529|sc-377454|sc-25296|sc-8348|sc-56005|

Name

Anti-Bag1 antibody

Catalogue No.

STJ99243

Immunogen

Purified recombinant human Bag1 protein fragments expressed in E.coli.

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Molecular weight

52/46/33kDa

Formulation

Anti-Bag1 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-Bag1 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Bag 1 antibody, BAG family molecular chaperone regulator 1 antibody, BAG-1 antibody, BAG1 antibody, BAG1_HUMAN antibody, BCL 2 Associated Athanogene 1 antibody, BCL 2 associated athanogene antibody, BCL 2 binding athanogene 1 antibody, Bcl-2-associated athanogene 1 antibody, BCL2 associated athanogene 1 antibody, BCL2 associated athanogene antibody, Glucocorticoid receptor-associated protein RAP46 antibody, HAP1 antibody, Haptoglobin antibody, RAP 46 antibody, RAP46 antibody

Database links

UniProt/Swiss-Prot:Q99933

Protein function

Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli. .

Protein tissue specificity

Isoform 4 is the most abundantly expressed isoform. It is ubiquitously expressed throughout most tissues, except the liver, colon, breast and uterine myometrium. Isoform 1 is expressed in the ovary and testis. Isoform 4 is expressed in several types of tumor cell lines, and at consistently high levels in leukemia and lymphoma cell lines. Isoform 1 is expressed in the prostate, breast and leukemia cell lines. Isoform 3 is the least abundant isoform in tumor cell lines (at protein level). .

Protein sequence and domain

Contains 1 BAG domain. ; Contains 1 ubiquitin-like domain.

Protein post-translational modifications

Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation. .

Protein cellular localization

Isoform 1: Nucleus. Cytoplasm. Note=Isoform 1 localizes predominantly to the nucleus.; Isoform 2: Cytoplasm. Nucleus. Note=Isoform 2 localizes to the cytoplasm and shuttles into the nucleus in response to heat shock.; Isoform 4: Cytoplasm. Nucleus. Note=Isoform 4 localizes predominantly to the cytoplasm. The cellular background in which it is expressed can influence whether it resides primarily in the cytoplasm or is also found in the nucleus. In the presence of BCL2, localizes to intracellular membranes (what appears to be the nuclear envelope and perinuclear membranes) as well as punctate cytosolic structures suggestive of mitochondria.

Research area

All research areas>Tumor Suppressor/Apoptosis>Bag
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize Anti-Bag1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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