Mouse Monoclonal Anti-beta-Tubulin antibody (STJ99132)

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Reactivity: Human, Mouse, Monkey, Goat, Hamster, Rat, chlamydomonas
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Anti-beta-Tubulin antibody (STJ99132)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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|beta 4 tubulin antibody|Beta 5 tubulin antibody|beta Ib tubulin antibody|M40 antibody|TBB5_HUMAN antibody|TUBB antibody|TUBB1 antibody|TUBB5 antibody|tubulin beta 1 chain antibody|Tubulin beta 5 chain antibody|Tubulin beta antibody|Tubulin beta chain antibody|tubulin beta polypeptide antibody|Tubulin beta-5 chain antibody|Anti-beta Tubulin antibody – Loading Control (ab6046)
SCBT cat No: sc-101527|sc-53140|sc-80011|sc-5274|sc-86255|sc-166729|sc-55529|sc-9104|sc-58882|sc-31782|sc-9935|sc-58884|

Name

Anti-beta-Tubulin antibody

Catalogue No.

STJ99132

Reactivity

Human, Mouse, Monkey, Goat, Hamster, Rat, chlamydomonas

Specificity

Anti-beta-Tubulin antibody detects endogenous levels of Tubulin beta and does not cross-react with related proteins.

Immunogen

Purified recombinant human Tubulin beta protein fragments expressed in E.coli.

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Molecular weight

55kDa

Formulation

Anti-beta-Tubulin antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-beta-Tubulin antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

beta 4 tubulin antibody, Beta 5 tubulin antibody, beta Ib tubulin antibody, M40 antibody, TBB5_HUMAN antibody, TUBB antibody, TUBB1 antibody, TUBB5 antibody, tubulin beta 1 chain antibody, Tubulin beta 5 chain antibody, Tubulin beta antibody, Tubulin beta chain antibody, tubulin beta polypeptide antibody, Tubulin beta-5 chain antibody

Database links

UniProt/Swiss-Prot:P07437

Protein function

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Protein tissue specificity

Ubiquitously expressed with highest levels in spleen, thymus and immature brain. .

Involvement in disease

Cortical dysplasia, complex, with other brain malformations 6 (CDCBM6) [MIM:615771]: A disorder of aberrant neuronal migration and disturbed axonal guidance. Affected individuals have microcephaly, ataxia, and severe delayed psychomotor development. Brain imaging shows variable malformations of cortical development, including white matter streaks, dysmorphic basal ganglia, corpus callosum abnormalities, brainstem and cerebellar hypoplasia, cortical dysplasia, polymicrogyria. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Skin creases, congenital symmetric circumferential, 1 (CSCSC1) [MIM:156610]: An autosomal dominant disease characterized by multiple, symmetric, circumferential rings of folded skin, affecting primarily the limbs. Affected individuals also exhibit intellectual disability, cleft palate, and dysmorphic features. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the tubulin family. The highly acidic C-terminal region may bind cations such as calcium.

Protein post-translational modifications

Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:26875866). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866). .; Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear (Probable). .; Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules. .

Protein cellular localization

Cytoplasm, cytoskeleton .

Research area

All research areas>Structural Proteins>Tubulin
(View all antibody categories related to Structural Proteins)

Note

AntibodyPlus can customize Anti-beta-Tubulin antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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