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Mouse Monoclonal Anti-beta-Tubulin antibody (STJ99132)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-beta-Tubulin antibody.
Check alternative names for the antibodyExpand
|beta 4 tubulin antibody|Beta 5 tubulin antibody|beta Ib tubulin antibody|M40 antibody|TBB5_HUMAN antibody|TUBB antibody|TUBB1 antibody|TUBB5 antibody|tubulin beta 1 chain antibody|Tubulin beta 5 chain antibody|Tubulin beta antibody|Tubulin beta chain antibody|tubulin beta polypeptide antibody|Tubulin beta-5 chain antibody|Anti-beta Tubulin antibody – Loading Control (ab6046)
SCBT cat No: sc-101527|sc-53140|sc-80011|sc-5274|sc-86255|sc-166729|sc-55529|sc-9104|sc-58882|sc-31782|sc-9935|sc-58884|
|Catalogue No.|| |
Human, Mouse, Monkey, Goat, Hamster, Rat, chlamydomonas
Anti-beta-Tubulin antibody detects endogenous levels of Tubulin beta and does not cross-react with related proteins.
Purified recombinant human Tubulin beta protein fragments expressed in E.coli.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-beta-Tubulin antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-beta-Tubulin antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
beta 4 tubulin antibody, Beta 5 tubulin antibody, beta Ib tubulin antibody, M40 antibody, TBB5_HUMAN antibody, TUBB antibody, TUBB1 antibody, TUBB5 antibody, tubulin beta 1 chain antibody, Tubulin beta 5 chain antibody, Tubulin beta antibody, Tubulin beta chain antibody, tubulin beta polypeptide antibody, Tubulin beta-5 chain antibody
|Database links|| |
|Protein function|| |
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
|Protein tissue specificity|| |
Ubiquitously expressed with highest levels in spleen, thymus and immature brain. .
|Involvement in disease|| |
Cortical dysplasia, complex, with other brain malformations 6 (CDCBM6) [MIM:615771]: A disorder of aberrant neuronal migration and disturbed axonal guidance. Affected individuals have microcephaly, ataxia, and severe delayed psychomotor development. Brain imaging shows variable malformations of cortical development, including white matter streaks, dysmorphic basal ganglia, corpus callosum abnormalities, brainstem and cerebellar hypoplasia, cortical dysplasia, polymicrogyria. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Skin creases, congenital symmetric circumferential, 1 (CSCSC1) [MIM:156610]: An autosomal dominant disease characterized by multiple, symmetric, circumferential rings of folded skin, affecting primarily the limbs. Affected individuals also exhibit intellectual disability, cleft palate, and dysmorphic features. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the tubulin family. The highly acidic C-terminal region may bind cations such as calcium.
|Protein post-translational modifications|| |
Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:26875866). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866). .; Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear (Probable). .; Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules. .
|Protein cellular localization|| |
Cytoplasm, cytoskeleton .
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St John’s Laboratory Ltd.
|Product type|| |
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