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Mouse Monoclonal Anti-CaMKIV antibody (STJ99119)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-CaMKIV antibody.
Check alternative names for the antibodyExpand
|Brain Ca(2+) calmodulin dependent protein kinase type 4 antibody|Brain Ca(2+) calmodulin dependent protein kinase type IV antibody|Brain Ca++-calmodulin dependent protein kinase type IV antibody|Calcium / calmodulin dependent protein kinase type 4 catalytic chain antibody|Calcium / calmodulin dependent protein kinase type IV catalytic chain antibody|Calcium/calmodulin dependent protein kinase IV antibody|Calcium/calmodulin dependent protein kinase type IV antibody|Calcium/calmodulin-dependent protein kinase type IV antibody|CAM kinase 4 antibody|CAM kinase GR antibody|CAM kinase IV antibody|CAM kinase-GR antibody|CaMK 4 antibody|CAMK GR antibody|CaMK IV antibody|Camk4 antibody|CaMKGR antibody|IV antibody|KCC4_HUMAN antibody|MGC36771 antibody|Anti-CAMKIV antibody (ab3557)
SCBT cat No: sc-136249|sc-166156|sc-166157|sc-1545|sc-17762|sc-9036|sc-55501|
|Catalogue No.|| |
Anti-CaMKIV antibody detects endogenous levels of CaMKIV and does not cross-react with related proteins.
Purified recombinant human CaMKIV protein fragments expressed in E.coli.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-CaMKIV antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-CaMKIV antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Brain Ca(2+) calmodulin dependent protein kinase type 4 antibody, Brain Ca(2+) calmodulin dependent protein kinase type IV antibody, Brain Ca++-calmodulin dependent protein kinase type IV antibody, Calcium / calmodulin dependent protein kinase type 4 catalytic chain antibody, Calcium / calmodulin dependent protein kinase type IV catalytic chain antibody, Calcium/calmodulin dependent protein kinase IV antibody, Calcium/calmodulin dependent protein kinase type IV antibody, Calcium/calmodulin-dependent protein kinase type IV antibody, CAM kinase 4 antibody, CAM kinase GR antibody, CAM kinase IV antibody, CAM kinase-GR antibody, CaMK 4 antibody, CAMK GR antibody, CaMK IV antibody, Camk4 antibody, CaMKGR antibody, IV antibody, KCC4_HUMAN antibody, MGC36771 antibody
|Database links|| |
|Protein function|| |
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18. .
|Protein tissue specificity|| |
Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue. .
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. ; Contains 1 protein kinase domain. The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate.
|Protein post-translational modifications|| |
Phosphorylated by CaMKK1 and CaMKK2 on Thr-200. Dephosphorylated by protein phosphatase 2A. Autophosphorylated on Ser-12 and Ser-13. .; Glycosylation at Ser-189 modulates the phosphorylation of CaMK4 at Thr-200 and negatively regulates its activity toward CREB1 in basal conditions and during early inomycin stimulation. .
|Protein cellular localization|| |
Cytoplasm. Nucleus. Note=Localized in hippocampal neuron nuclei. In spermatids, associated with chromatin and nuclear matrix (By similarity). .
|Research area|| |
<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Kinases-and-Phosphatases/">Kinases and Phosphatases</a>><a href="http://antibodyplus.com/product-tag/CaMK/">CaMK</a><br><a href="http://antibodyplus.com/product-tag/Kinases-and-Phosphatases/"> (View all antibody categories related to Kinases and Phosphatases)</a>
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St John’s Laboratory Ltd.
|Product type|| |
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