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Mouse Monoclonal Anti-Caspase-9 antibody (STJ99219)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-Caspase-9 antibody.
Check alternative names for the antibodyExpand
|APAF-3 antibody|Apoptotic protease Mch-6 antibody|Caspase 9 Dominant Negative antibody|Caspase 9c antibody|Caspase-9 antibody|Caspase-9 subunit p10 antibody|ICE LAP6 antibody|ICE like apoptotic protease 6 antibody|ICE-LAP6 antibody|ICE-like apoptotic protease 6 antibody|MCH6 antibody|PPP1R56 antibody|protein phosphatase 1, regulatory subunit 56 antibody|RNCASP9 antibody|Anti-Caspase-9 antibody [E23] (ab32539)
SCBT cat No: sc-81650|sc-56073|sc-70505|sc-70506|sc-70507|sc-56076|sc-81663|sc-81589|sc-73548|sc-56077|sc-8297|sc-17784|sc-7885|sc-133109|sc-8355|sc-374489|sc-373777|
|Catalogue No.|| |
Anti-Caspase-9 antibody detects endogenous levels of Caspase-9 and does not cross-react with related proteins.
Purified recombinant human Caspase-9 protein fragments expressed in E.coli.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-Caspase-9 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-Caspase-9 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
APAF-3 antibody, Apoptotic protease Mch-6 antibody, Caspase 9 Dominant Negative antibody, Caspase 9c antibody, Caspase-9 antibody, Caspase-9 subunit p10 antibody, ICE LAP6 antibody, ICE like apoptotic protease 6 antibody, ICE-LAP6 antibody, ICE-like apoptotic protease 6 antibody, MCH6 antibody, PPP1R56 antibody, protein phosphatase 1, regulatory subunit 56 antibody, RNCASP9 antibody
|Database links|| |
|Protein function|| |
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).; Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
|Protein tissue specificity|| |
Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes. .
|Protein sequence and domain|| |
Belongs to the peptidase C14A family. ; Contains 1 CARD domain.
|Protein post-translational modifications|| |
Cleavages at Asp-315 by granzyme B and at Asp-330 by caspase-3 generate the two active subunits. Caspase-8 and -10 can also be involved in these processing events.; Phosphorylated at Thr-125 by MAPK1/ERK2. Phosphorylation at Thr-125 is sufficient to block caspase-9 processing and subsequent caspase-3 activation. Phosphorylation on Tyr-153 by ABL1/c-Abl; occurs in the response of cells to DNA damage. .
|Research area|| |
<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Tumor-SuppressorApoptosis/">Tumor Suppressor/Apoptosis</a>><a href="http://antibodyplus.com/product-tag/Caspase/">Caspase</a><br><a href="http://antibodyplus.com/product-tag/Tumor-SuppressorApoptosis/"> (View all antibody categories related to Tumor Suppressor/Apoptosis)</a>
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St John’s Laboratory Ltd.
|Product type|| |
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