Mouse Monoclonal Anti-CHRDL1 antibody (STJ99125)

$99.00$319.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Anti-CHRDL1 antibody (STJ99125)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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|CHL antibody|chordin like 1 antibody|Chordin-like protein 1 antibody|CHRDL1 antibody|CRDL1_HUMAN antibody|dA141H5.1 antibody|neuralin 1 antibody|Neuralin-1 antibody|Neurogenesin-1 antibody|NRLN1 antibody|Ventroptin antibody|VOPT antibody|Anti-CHRDL1 antibody (ab103369)
SCBT cat No: sc-100333|

Name

Anti-CHRDL1 antibody

Catalogue No.

STJ99125

Reactivity

Human

Specificity

Anti-CHRDL1 antibody detects endogenous levels of CHRDL1 and does not cross-react with related proteins.

Immunogen

Purified recombinant human CHRDL1 protein fragments expressed in E.coli.

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Molecular weight

52kDa

Formulation

Anti-CHRDL1 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-CHRDL1 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

CHL antibody, chordin like 1 antibody, Chordin-like protein 1 antibody, CHRDL1 antibody, CRDL1_HUMAN antibody, dA141H5.1 antibody, neuralin 1 antibody, Neuralin-1 antibody, Neurogenesin-1 antibody, NRLN1 antibody, Ventroptin antibody, VOPT antibody

Database links

UniProt/Swiss-Prot:Q9BU40

Protein function

Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development. .

Protein tissue specificity

Expressed in the developing cornea and in the eye anterior segment in addition to the retina. Differentially expressed in the fetal brain. There is high expression in cerebellum and neocortex. Expressed in retinal pericytes. .

Involvement in disease

Megalocornea 1, X-linked (MGC1) [MIM:309300]: An eye disorder in which the corneal diameter is bilaterally enlarged (greater than 13 mm) without an increase in intraocular pressure. It may also be referred to as anterior megalophthalmos, since the entire anterior segment is larger than normal. Features of megalocornea in addition to a deep anterior chamber include astigmatic refractive errors, atrophy of the iris stroma, miosis secondary to decreased function of the dilator muscle, iridodonesis, and tremulousness, subluxation, or dislocation of the lens. Whereas most affected individuals exhibit normal ocular function, complications include cataract development and glaucoma following lenticular dislocation or subluxation. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Contains 3 VWFC domains.

Protein cellular localization

Secreted .

Research area

All research areas>Neurobiology>CHRDL
(View all antibody categories related to Neurobiology)

Note

AntibodyPlus can customize Anti-CHRDL1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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