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Mouse Monoclonal Anti-cIAP2 antibody (STJ99165)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-cIAP2 antibody.
Check alternative names for the antibodyExpand
|AIP 1 antibody|AIP1 antibody|API 2 antibody|API2 antibody|Apoptosis inhibitor 2 antibody|Baculoviral IAP repeat containing 3 antibody|Baculoviral IAP repeat containing protein 3 antibody|Baculoviral IAP repeat-containing protein 3 antibody|BIRC 3 antibody|BIRC3 antibody|BIRC3_HUMAN antibody|C IAP2 antibody|C-IAP2 antibody|CIAP 2 antibody|CIAP2 antibody|HAIP 1 antibody|HAIP1 antibody|HIAP 1 antibody|HIAP-1 antibody|HIAP1 antibody|IAP homolog C antibody|IAP-1 antibody|Inhibitor of apoptosis protein 1 antibody|MALT 2 antibody|MALT2 antibody|Mammalian IAP homolog C antibody|MIHC antibody|RING finger protein 49 antibody|RNF49 antibody|TNFR2 TRAF signaling complex protein 1 antibody|TNFR2 TRAF signalling complex protein antibody|TNFR2-TRAF-signaling complex protein 1 antibody|Anti-cIAP2 antibody (ab23423)
SCBT cat No: sc-1957|sc-7944|
|Catalogue No.|| |
Anti-cIAP2 antibody detects endogenous levels of c-IAP2 and does not cross-react with related proteins.
Purified recombinant human c-IAP2 protein fragments expressed in E.coli
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-cIAP2 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-cIAP2 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
AIP 1 antibody, AIP1 antibody, API 2 antibody, API2 antibody, Apoptosis inhibitor 2 antibody, Baculoviral IAP repeat containing 3 antibody, Baculoviral IAP repeat containing protein 3 antibody, Baculoviral IAP repeat-containing protein 3 antibody, BIRC 3 antibody, BIRC3 antibody, BIRC3_HUMAN antibody, C IAP2 antibody, C-IAP2 antibody, CIAP 2 antibody, CIAP2 antibody, HAIP 1 antibody, HAIP1 antibody, HIAP 1 antibody, HIAP-1 antibody, HIAP1 antibody, IAP homolog C antibody, IAP-1 antibody, Inhibitor of apoptosis protein 1 antibody, MALT 2 antibody, MALT2 antibody, Mammalian IAP homolog C antibody, MIHC antibody, RING finger protein 49 antibody, RNF49 antibody, TNFR2 TRAF signaling complex protein 1 antibody, TNFR2 TRAF signalling complex protein antibody, TNFR2-TRAF-signaling complex protein 1 antibody
|Database links|| |
|Protein function|| |
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. .
|Protein tissue specificity|| |
Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes.
|Involvement in disease|| |
Note=A chromosomal aberration involving BIRC3 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with MALT1. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.
|Protein sequence and domain|| |
Belongs to the IAP family. ; Contains 3 BIR repeats. ; Contains 1 CARD domain. ; Contains 1 RING-type zinc finger.
|Protein post-translational modifications|| |
Auto-ubiquitinated and degraded by the proteasome in apoptotic cells.
|Protein cellular localization|| |
Cytoplasm . Nucleus .
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St John’s Laboratory Ltd.
|Product type|| |
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