Mouse Monoclonal Anti-cIAP2 antibody (STJ99165)

$99.00$319.00

Reactivity: Human, Monkey
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Anti-cIAP2 antibody (STJ99165)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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|AIP 1 antibody|AIP1 antibody|API 2 antibody|API2 antibody|Apoptosis inhibitor 2 antibody|Baculoviral IAP repeat containing 3 antibody|Baculoviral IAP repeat containing protein 3 antibody|Baculoviral IAP repeat-containing protein 3 antibody|BIRC 3 antibody|BIRC3 antibody|BIRC3_HUMAN antibody|C IAP2 antibody|C-IAP2 antibody|CIAP 2 antibody|CIAP2 antibody|HAIP 1 antibody|HAIP1 antibody|HIAP 1 antibody|HIAP-1 antibody|HIAP1 antibody|IAP homolog C antibody|IAP-1 antibody|Inhibitor of apoptosis protein 1 antibody|MALT 2 antibody|MALT2 antibody|Mammalian IAP homolog C antibody|MIHC antibody|RING finger protein 49 antibody|RNF49 antibody|TNFR2 TRAF signaling complex protein 1 antibody|TNFR2 TRAF signalling complex protein antibody|TNFR2-TRAF-signaling complex protein 1 antibody|Anti-cIAP2 antibody (ab23423)
SCBT cat No: sc-1957|sc-7944|

Name

Anti-cIAP2 antibody

Catalogue No.

STJ99165

Reactivity

Human, Monkey

Specificity

Anti-cIAP2 antibody detects endogenous levels of c-IAP2 and does not cross-react with related proteins.

Immunogen

Purified recombinant human c-IAP2 protein fragments expressed in E.coli

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Molecular weight

72kDa

Formulation

Anti-cIAP2 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-cIAP2 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

AIP 1 antibody, AIP1 antibody, API 2 antibody, API2 antibody, Apoptosis inhibitor 2 antibody, Baculoviral IAP repeat containing 3 antibody, Baculoviral IAP repeat containing protein 3 antibody, Baculoviral IAP repeat-containing protein 3 antibody, BIRC 3 antibody, BIRC3 antibody, BIRC3_HUMAN antibody, C IAP2 antibody, C-IAP2 antibody, CIAP 2 antibody, CIAP2 antibody, HAIP 1 antibody, HAIP1 antibody, HIAP 1 antibody, HIAP-1 antibody, HIAP1 antibody, IAP homolog C antibody, IAP-1 antibody, Inhibitor of apoptosis protein 1 antibody, MALT 2 antibody, MALT2 antibody, Mammalian IAP homolog C antibody, MIHC antibody, RING finger protein 49 antibody, RNF49 antibody, TNFR2 TRAF signaling complex protein 1 antibody, TNFR2 TRAF signalling complex protein antibody, TNFR2-TRAF-signaling complex protein 1 antibody

Database links

UniProt/Swiss-Prot:Q13489

Protein function

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. .

Protein tissue specificity

Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes.

Involvement in disease

Note=A chromosomal aberration involving BIRC3 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with MALT1. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.

Protein sequence and domain

Belongs to the IAP family. ; Contains 3 BIR repeats. ; Contains 1 CARD domain. ; Contains 1 RING-type zinc finger.

Protein post-translational modifications

Auto-ubiquitinated and degraded by the proteasome in apoptotic cells.

Protein cellular localization

Cytoplasm . Nucleus .

Note

AntibodyPlus can customize Anti-cIAP2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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