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Mouse Monoclonal Anti-CrkII antibody (STJ99163)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
|Adapter molecule crk antibody|Avian sarcoma virus CT10 (v crk) oncogene homolog antibody|CRK antibody|CRK isoform 2 antibody|CRK isoform II antibody|CRK_HUMAN antibody|CRKII antibody|FLJ38130 antibody|OTTHUMP00000115366 antibody|OTTHUMP00000198330 antibody|p38 antibody|Proto oncogene C crk antibody|Proto-oncogene C-crk antibody|v crk avian sarcoma virus CT10 oncogene homolog antibody|v crk sarcoma virus CT10 oncogene homolog antibody|v crk sarcoma virus CT10 oncogene homolog (avian) antibody|Anti-Crk p38 antibody [EPR4984(2)] (ab133581)
SCBT cat No: sc-393160|sc-23775|sc-17989|sc-81234|sc-390132|sc-289|sc-9004|
|Catalogue No.|| |
Anti-CrkII antibody detects endogenous levels of CrkII and does not cross-react with related proteins.
Purified recombinant human CrkII protein fragments expressed in E.coli.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-CrkII antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-CrkII antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Adapter molecule crk antibody, Avian sarcoma virus CT10 (v crk) oncogene homolog antibody, CRK antibody, CRK isoform 2 antibody, CRK isoform II antibody, CRK_HUMAN antibody, CRKII antibody, FLJ38130 antibody, OTTHUMP00000115366 antibody, OTTHUMP00000198330 antibody, p38 antibody, Proto oncogene C crk antibody, Proto-oncogene C-crk antibody, v crk avian sarcoma virus CT10 oncogene homolog antibody, v crk sarcoma virus CT10 oncogene homolog antibody, v crk sarcoma virus CT10 oncogene homolog (avian) antibody
|Database links|| |
|Protein function|| |
Isoform Crk-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. .
|Protein sequence and domain|| |
Belongs to the CRK family. ; Contains 1 SH2 domain. ; Contains 2 SH3 domains. The C-terminal SH3 domain function as a negative modulator for transformation and the N-terminal SH3 domain appears to function as a positive regulator for transformation. ; The SH2 domain mediates interaction with tyrosine phosphorylated proteins. Mediates interaction with SHB.
|Protein post-translational modifications|| |
Phosphorylation of Crk-II (40 kDa) gives rise to a 42 kDa form. Isoform Crk-II is phosphorylated by KIT.; Phosphorylated on Tyr-221 upon cell adhesion. Results in the negative regulation of the association with SH2- and SH3-binding partners, possibly by the formation of an intramolecular interaction of phosphorylated Tyr-221 with the SH2 domain. This leads finally to the down-regulation of the Crk signaling pathway. .; Proline isomerization at Pro-237 by PPIA acts as a switch between two conformations: an autoinhibitory conformation in the cis form, where the tandem SH3 domains interact intramolecularly, and an activated conformation in the trans form. .
|Protein cellular localization|| |
Cytoplasm . Cell membrane . Note=Translocated to the plasma membrane upon cell adhesion. .
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St John’s Laboratory Ltd.
|Product type|| |
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