Mouse Monoclonal Anti-CSK antibody (STJ99130)

$99.00$319.00

Reactivity: Human, Rat
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Anti-CSK antibody (STJ99130)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

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SCBT cat No:

Name

Anti-CSK antibody

Catalogue No.

STJ99130

Reactivity

Human, Rat

Specificity

Anti-CSK antibody detects endogenous levels of CSK and does not cross-react with related proteins.

Immunogen

Purified recombinant human CSK protein fragments expressed in E.coli.

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG2b

Molecular weight

50kDa

Formulation

Anti-CSK antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-CSK antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Database links

UniProt/Swiss-Prot:P41240

Protein function

Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. .

Protein tissue specificity

Expressed in lung and macrophages. .

Protein sequence and domain

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily. ; Contains 1 protein kinase domain. ; Contains 1 SH2 domain. ; Contains 1 SH3 domain. The architecture of this protein is similar to that of Src-family kinases (SFKs) with one N-terminal SH3 domain, one SH2 domain, and a C-terminal kinase domain.

Protein post-translational modifications

Phosphorylated at Ser-364 by PKA, leading to increased activity. Autophosphorylated. .

Protein cellular localization

Cytoplasm . Cell membrane . Note=Mainly cytoplasmic, also present in lipid rafts. .

Note

AntibodyPlus can customize Anti-CSK antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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