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Mouse Monoclonal Anti-CSK antibody (STJ99130)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
SCBT cat No:
|Catalogue No.|| |
Anti-CSK antibody detects endogenous levels of CSK and does not cross-react with related proteins.
Purified recombinant human CSK protein fragments expressed in E.coli.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-CSK antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-CSK antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Database links|| |
|Protein function|| |
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. .
|Protein tissue specificity|| |
Expressed in lung and macrophages. .
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily. ; Contains 1 protein kinase domain. ; Contains 1 SH2 domain. ; Contains 1 SH3 domain. The architecture of this protein is similar to that of Src-family kinases (SFKs) with one N-terminal SH3 domain, one SH2 domain, and a C-terminal kinase domain.
|Protein post-translational modifications|| |
Phosphorylated at Ser-364 by PKA, leading to increased activity. Autophosphorylated. .
|Protein cellular localization|| |
Cytoplasm . Cell membrane . Note=Mainly cytoplasmic, also present in lipid rafts. .
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St John’s Laboratory Ltd.
|Product type|| |
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