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Mouse Monoclonal Anti-Cyclin D2 antibody (STJ99098)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-Cyclin D2 antibody.
Check alternative names for the antibodyExpand
|CCND 2 antibody|ccnd2 antibody|CCND2_HUMAN antibody|CyclinD2 antibody|G1/S specific cyclin D2 antibody|G1/S-specific cyclin-D2 antibody|KIAK0002 antibody|MGC102758 antibody|Anti-Cyclin D2 antibody [DCS-3.1] (ab3085)
SCBT cat No: sc-593|
Anti-Cyclin D2 antibody
|Catalogue No.|| |
Anti-Cyclin D2 antibody detects over-expressed levels of Cyclin D2 and does not cross-react with related proteins.
Purified recombinant human Cyclin D2 protein fragments expressed in E.coli.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-Cyclin D2 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-Cyclin D2 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
CCND 2 antibody, ccnd2 antibody, CCND2_HUMAN antibody, CyclinD2 antibody, G1/S specific cyclin D2 antibody, G1/S-specific cyclin-D2 antibody, KIAK0002 antibody, MGC102758 antibody
|Database links|| |
|Protein function|| |
Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity). .
|Involvement in disease|| |
Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3) [MIM:615938]: A syndrome characterized by megalencephaly, ventriculomegaly that may lead to hydrocephalus, and polymicrogyria; polydactyly may also be seen. There is considerable phenotypic similarity between this disorder and the megalencephaly-capillary malformation syndrome. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the cyclin family. Cyclin D subfamily. ; Contains 1 cyclin N-terminal domain.
|Protein post-translational modifications|| |
Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation. .
|Protein cellular localization|| |
Nucleus . Cytoplasm . Membrane . Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members. .; Isoform 2: Cytoplasm .
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St John’s Laboratory Ltd.
|Product type|| |
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