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Mouse Monoclonal Anti-DDB1 antibody (STJ99189)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-DDB1 antibody.
Check alternative names for the antibodyExpand
|Damage-specific DNA-binding protein 1 antibody|DDB p127 subunit antibody|Ddb1 antibody|DDB1_HUMAN antibody|DDBa antibody|DNA damage-binding protein 1 antibody|DNA damage-binding protein a antibody|HBV X-associated protein 1 antibody|UV-damaged DNA-binding factor antibody|UV-damaged DNA-binding protein 1 antibody|UV-DDB 1 antibody|XAP-1 antibody|Xeroderma pigmentosum group E-complementing protein antibody|XPCe antibody|XPE-BF antibody|XPE-binding factor antibody|Anti-DDB1 with anti-GAPDH internal loading control antibody (ab75393)
SCBT cat No: sc-136180|sc-137142|sc-137132|sc-376860|sc-25367|sc-16292|
|Catalogue No.|| |
Human, Mouse, Rat, Monkey
Anti-DDB1 antibody detects endogenous levels of DDB1 and does not cross-react with related proteins.
Purified recombinant human DDB1 protein fragments expressed in E.coli.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-DDB1 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-DDB1 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Damage-specific DNA-binding protein 1 antibody, DDB p127 subunit antibody, Ddb1 antibody, DDB1_HUMAN antibody, DDBa antibody, DNA damage-binding protein 1 antibody, DNA damage-binding protein a antibody, HBV X-associated protein 1 antibody, UV-damaged DNA-binding factor antibody, UV-damaged DNA-binding protein 1 antibody, UV-DDB 1 antibody, XAP-1 antibody, Xeroderma pigmentosum group E-complementing protein antibody, XPCe antibody, XPE-BF antibody, XPE-binding factor antibody
|Database links|| |
|Protein function|| |
Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1. DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR). May also play a role in ubiquitination of CDKN1B/p27kip when associated with CUL4 and SKP2. .
|Protein sequence and domain|| |
Belongs to the DDB1 family. The core of the protein consists of three WD40 beta-propeller domains.
|Protein post-translational modifications|| |
Phosphorylated by ABL1. .; Ubiquitinated by CUL4A. Subsequently degraded by ubiquitin-dependent proteolysis. .
|Protein cellular localization|| |
Cytoplasm. Nucleus. Note=Primarily cytoplasmic. Translocates to the nucleus following UV irradiation and subsequently accumulates at sites of DNA damage.
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St John’s Laboratory Ltd.
|Product type|| |
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