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Mouse Monoclonal Anti-DR5 antibody (STJ99180)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-DR5 antibody.
Check alternative names for the antibodyExpand
|Fas like protein antibody|TNFRSF10B antibody|TR10B_HUMAN antibody|TRAIL R2 antibody|TRAIL receptor 2 antibody|TRAIL-R2 antibody|TRAILR2 antibody|TRICK2 antibody|TRICK2A antibody|TRICK2B antibody|TRICKB antibody|Tumor necrosis factor receptor like protein ZTNFR9 antibody|Tumor necrosis factor receptor superfamily member 10B antibody|Tumor necrosis factor receptor superfamily, member 10b antibody|ZTNFR9 antibody|Anti-DR5 antibody (ab8416)
SCBT cat No: sc-166624|
|Catalogue No.|| |
Anti-DR5 antibody detects endogenous levels of DR5 and does not cross-react with related proteins.
Purified recombinant human DR5 protein fragments expressed in E.coli.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-DR5 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-DR5 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Fas like protein antibody, TNFRSF10B antibody, TR10B_HUMAN antibody, TRAIL R2 antibody, TRAIL receptor 2 antibody, TRAIL-R2 antibody, TRAILR2 antibody, TRICK2 antibody, TRICK2A antibody, TRICK2B antibody, TRICKB antibody, Tumor necrosis factor receptor like protein ZTNFR9 antibody, Tumor necrosis factor receptor superfamily member 10B antibody, Tumor necrosis factor receptor superfamily, member 10b antibody, ZTNFR9 antibody
|Database links|| |
|Protein function|| |
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. .
|Protein tissue specificity|| |
Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.
|Involvement in disease|| |
Squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355]: A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes. Note=The disease may be caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Contains 1 death domain. ; Contains 3 TNFR-Cys repeats.
|Protein cellular localization|| |
Membrane; Single-pass type I membrane protein.
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St John’s Laboratory Ltd.
|Product type|| |
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