Mouse Monoclonal Anti-Eg5 antibody (STJ99033)

$99.00$319.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Anti-Eg5 antibody (STJ99033)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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|EG5 antibody|KNSL1 antibody|MCLMR antibody|Thyroid receptor-interacting protein 5 antibody|TR-interacting protein 5 antibody|TRIP-5 antibody|TRIP5 antibody|Anti-Eg5 antibody [mAbcam 51976] (ab51976)
SCBT cat No: sc-53691|sc-136223|sc-365681|sc-365593|sc-393311|

Name

Anti-Eg5 antibody

Catalogue No.

STJ99033

Reactivity

Human

Specificity

Anti-Eg5 antibody detects endogenous levels of Eg5 and does not cross-react with related proteins.

Immunogen

Purified recombinant human Eg5 protein fragments expressed in E.coli.

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Molecular weight

130kDa

Formulation

Anti-Eg5 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-Eg5 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

EG5 antibody, KNSL1 antibody, MCLMR antibody, Thyroid receptor-interacting protein 5 antibody, TR-interacting protein 5 antibody, TRIP-5 antibody, TRIP5 antibody

Database links

UniProt/Swiss-Prot:P52732

Protein function

Motor protein required for establishing a bipolar spindle during mitosis (PubMed:19001501). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). .

Involvement in disease

Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:152950]: An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. BimC subfamily. ; Contains 1 kinesin motor domain.

Protein post-translational modifications

Phosphorylated exclusively on serine during S phase, but on both serine and Thr-926 during mitosis, so controlling the association of KIF11 with the spindle apparatus (probably during early prophase). .; A subset of this protein primarily localized at the spindle pole is phosphorylated by NEK6 during mitosis; phosphorylation is required for mitotic function. .

Protein cellular localization

Cytoplasm . Cytoplasm, cytoskeleton, spindle pole .

Research area

All research areas>Structural Proteins>Eg5
(View all antibody categories related to Structural Proteins)

Note

AntibodyPlus can customize Anti-Eg5 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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