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Mouse Monoclonal Anti-FADD antibody (STJ99305)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
|FADD antibody|FADD protein antibody|FADD_HUMAN antibody|Fas (TNFRSF6) associated via death domain antibody|Fas associated via death domain antibody|Fas associating death domain containing protein antibody|Fas associating protein antibody|Fas associating protein with death domain antibody|Fas TNFRSF6 associated via death domain antibody|FAS-associated death domain protein antibody|FAS-associating death domain-containing protein antibody|GIG 3 antibody|GIG3 antibody|Growth inhibiting gene 3 protein antibody|Growth-inhibiting gene 3 protein antibody|H sapiens mRNA for mediator of receptor induced toxicity antibody|Mediator of receptor induced toxicity antibody|MGC8528 antibody|MORT 1 antibody|MORT1 antibody|Protein FADD antibody|Anti-FADD antibody (ab24533)
SCBT cat No: sc-271748|sc-134337|sc-292676|
|Catalogue No.|| |
Anti-FADD antibody detects endogenous levels of FADD and does not cross-react with related proteins.
Purified recombinant human FADD protein fragments expressed in E.coli.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-FADD antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-FADD antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
FADD antibody, FADD protein antibody, FADD_HUMAN antibody, Fas (TNFRSF6) associated via death domain antibody, Fas associated via death domain antibody, Fas associating death domain containing protein antibody, Fas associating protein antibody, Fas associating protein with death domain antibody, Fas TNFRSF6 associated via death domain antibody, FAS-associated death domain protein antibody, FAS-associating death domain-containing protein antibody, GIG 3 antibody, GIG3 antibody, Growth inhibiting gene 3 protein antibody, Growth-inhibiting gene 3 protein antibody, H sapiens mRNA for mediator of receptor induced toxicity antibody, Mediator of receptor induced toxicity antibody, MGC8528 antibody, MORT 1 antibody, MORT1 antibody, Protein FADD antibody
|Database links|| |
|Protein function|| |
Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. .
|Protein tissue specificity|| |
Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.
|Involvement in disease|| |
Infections, recurrent, associated with encephalopathy, hepatic dysfunction and cardiovascular malformations (IEHDCM) [MIM:613759]: A condition with biological features of autoimmune lymphoproliferative syndrome such as high-circulating CD4(-)CD8(-)TCR-alpha-beta(+) T-cell counts, and elevated IL10 and FASL levels. Affected individuals suffer from recurrent, stereotypical episodes of fever, encephalopathy, and mild liver dysfunction sometimes accompanied by generalized seizures. The episodes can be triggered by varicella zoster virus (VZV), measles mumps rubella (MMR) attenuated vaccine, parainfluenza virus, and Epstein-Barr virus (EBV). . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Contains 1 death domain. ; Contains 1 DED (death effector) domain. Contains a death domain involved in the binding of the corresponding domain within Fas receptor. ; The interaction between the FAS and FADD death domains is crucial for the formation of the death-inducing signaling complex (DISC).
|Research area|| |
<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Tumor-SuppressorApoptosis/">Tumor Suppressor/Apoptosis</a>><a href="http://antibodyplus.com/product-tag/FADD/">FADD</a><br><a href="http://antibodyplus.com/product-tag/Tumor-SuppressorApoptosis/"> (View all antibody categories related to Tumor Suppressor/Apoptosis)</a>
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St John’s Laboratory Ltd.
|Product type|| |
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