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Mouse Monoclonal Anti-FAS antibody (STJ99086)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
|ALPS 1A antibody|ALPS1A antibody|APO 1 antibody|Apo 1 antigen antibody|APO 1 cell surface antigen antibody|Apo-1 antigen antibody|APO1 antibody|Apo1 antigen antibody|APO1 cell surface antigen antibody|Apoptosis antigen 1 antibody|Apoptosis mediating surface antigen FAS antibody|Apoptosis-mediating surface antigen FAS antibody|APT 1 antibody|APT1 antibody|CD 95 antibody|CD 95 antigen antibody|CD95 antibody|CD95 antigen antibody|Delta Fas antibody|Delta Fas/APO 1/CD95 antibody|Delta Fas/APO1/CD95 antibody|Fas (TNF receptor superfamily, member 6) antibody|FAS 1 antibody|FAS 827dupA antibody|Fas AMA antibody|Fas antibody|FAS Antigen antibody|Fas cell surface death receptor antibody|FAS1 antibody|FASLG receptor antibody|FASTM antibody|sFAS antibody|Surface antigen APO1 antibody|TNF receptor superfamily, member 6 antibody|TNFRSF 6 antibody|TNFRSF6 antibody|TNR6_HUMAN antibody|Tumor necrosis factor receptor superfamily member 6 antibody|Anti-Fas antibody (ab82419)
SCBT cat No: sc-8009|sc-715|sc-21730|sc-7886|sc-74540|sc-716|sc-714|
|Catalogue No.|| |
Anti-FAS antibody detects endogenous levels of FAS (C-term) and does not cross-react with related proteins.
Purified recombinant human FAS (C-term) protein fragments expressed in E.coli.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-FAS antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-FAS antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
ALPS 1A antibody, ALPS1A antibody, APO 1 antibody, Apo 1 antigen antibody, APO 1 cell surface antigen antibody, Apo-1 antigen antibody, APO1 antibody, Apo1 antigen antibody, APO1 cell surface antigen antibody, Apoptosis antigen 1 antibody, Apoptosis mediating surface antigen FAS antibody, Apoptosis-mediating surface antigen FAS antibody, APT 1 antibody, APT1 antibody, CD 95 antibody, CD 95 antigen antibody, CD95 antibody, CD95 antigen antibody, Delta Fas antibody, Delta Fas/APO 1/CD95 antibody, Delta Fas/APO1/CD95 antibody, Fas (TNF receptor superfamily, member 6) antibody, FAS 1 antibody, FAS 827dupA antibody, Fas AMA antibody, Fas antibody, FAS Antigen antibody, Fas cell surface death receptor antibody, FAS1 antibody, FASLG receptor antibody, FASTM antibody, sFAS antibody, Surface antigen APO1 antibody, TNF receptor superfamily, member 6 antibody, TNFRSF 6 antibody, TNFRSF6 antibody, TNR6_HUMAN antibody, Tumor necrosis factor receptor superfamily member 6 antibody
|Database links|| |
|Protein function|| |
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). .
|Protein tissue specificity|| |
Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6. .
|Involvement in disease|| |
Autoimmune lymphoproliferative syndrome 1A (ALPS1A) [MIM:601859]: A disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Contains 1 death domain. ; Contains 3 TNFR-Cys repeats. Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.
|Protein post-translational modifications|| |
N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. .
|Protein cellular localization|| |
Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Secreted.; Isoform 3: Secreted.; Isoform 4: Secreted.; Isoform 5: Secreted.; Isoform 6: Secreted.
|Research area|| |
<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Tumor-SuppressorApoptosis/">Tumor Suppressor/Apoptosis</a>><a href="http://antibodyplus.com/product-tag/FAS-CD95/">FAS (CD95)</a><br><a href="http://antibodyplus.com/product-tag/Tumor-SuppressorApoptosis/"> (View all antibody categories related to Tumor Suppressor/Apoptosis)</a>
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St John’s Laboratory Ltd.
|Product type|| |
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