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Mouse Monoclonal Anti-GRK2 antibody (STJ99115)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-GRK2 antibody.
Check alternative names for the antibodyExpand
|ADRBK1 antibody|Adrenergic beta receptor kinase 1 antibody|ARBK1_HUMAN antibody|BARK antibody|BARK1 antibody|Beta adrenergic receptor kinase 1 antibody|Beta ARK 1 antibody|Beta ARK1 antibody|Beta-adrenergic receptor kinase 1 antibody|Beta-ARK-1 antibody|FLJ16718 antibody|G protein coupled receptor kinase 2 antibody|G-protein coupled receptor kinase 2 antibody|GRK2 antibody|Anti-GRK2 antibody – C-terminal (ab137666)
SCBT cat No: sc-562|sc-18409|sc-13143|sc-166283|sc-166284|sc-271359|sc-8329|
|Catalogue No.|| |
Anti-GRK2 antibody detects endogenous levels of GRK2 and does not cross-react with related proteins.
Purified recombinant human GRK2 protein fragments expressed in E.coli.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-GRK2 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-GRK2 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
ADRBK1 antibody, Adrenergic beta receptor kinase 1 antibody, ARBK1_HUMAN antibody, BARK antibody, BARK1 antibody, Beta adrenergic receptor kinase 1 antibody, Beta ARK 1 antibody, Beta ARK1 antibody, Beta-adrenergic receptor kinase 1 antibody, Beta-ARK-1 antibody, FLJ16718 antibody, G protein coupled receptor kinase 2 antibody, G-protein coupled receptor kinase 2 antibody, GRK2 antibody
|Database links|| |
|Protein function|| |
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. .
|Protein tissue specificity|| |
Expressed in peripheral blood leukocytes. .
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. ; Contains 1 AGC-kinase C-terminal domain. ; Contains 1 PH domain. ; Contains 1 protein kinase domain. ; Contains 1 RGS domain. The PH domain binds anionic phospholipids and helps recruiting ADRBK1 from the cytoplasm to plasma membrane close to activated receptors. It mediates binding to G protein beta and gamma subunits, competing with G-alpha subunits and other G-betagamma effectors.
|Protein cellular localization|| |
Cytoplasm . Cell membrane .
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St John’s Laboratory Ltd.
|Product type|| |
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