Mouse Monoclonal Anti-HAUSP/USP7 antibody (STJ99076)

$99.00$319.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Anti-HAUSP/USP7 antibody (STJ99076)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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|Deubiquitinating enzyme 7 antibody|HAUSP antibody|Herpes virus associated ubiquitin specific protease antibody|Herpesvirus-associated ubiquitin-specific protease antibody|TEF 1 antibody|tef-1 antibody|TEF1 antibody|Ubiquitin carboxyl terminal hydrolase 7 antibody|Ubiquitin carboxyl-terminal hydrolase 7 antibody|Ubiquitin specific peptidase 7 (herpes virus associated) antibody|Ubiquitin specific peptidase 7 antibody|Ubiquitin specific peptidase 7 herpes virus associated antibody|Ubiquitin specific processing protease 7 antibody|Ubiquitin specific protease 7 (herpes virus associated) antibody|Ubiquitin specific protease 7 antibody|Ubiquitin specific protease 7 herpes virus associated antibody|Ubiquitin thioesterase 7 antibody|Ubiquitin thiolesterase 7 antibody|Ubiquitin-specific-processing protease 7 antibody|UBP 7 antibody|UBP-7 antibody|UBP7 antibody|UBP7_HUMAN antibody|USP 7 antibody|usp-7 antibody|Usp7 antibody|VMW110-ASSOCIATED PROTEIN, 135-KD antibody|Anti-HAUSP / USP7 antibody (ab4080)
SCBT cat No: sc-133204|sc-137001|sc-376912|sc-377147|sc-137008|sc-30164|sc-22848|

Name

Anti-HAUSP/USP7 antibody

Catalogue No.

STJ99076

Reactivity

Human

Specificity

Anti-HAUSP/USP7 antibody detects endogenous levels of HAUSP / USP7 and does not cross-react with related proteins.

Immunogen

Purified recombinant human HAUSP / USP7 protein fragments expressed in E.coli.

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Molecular weight

135kDa

Formulation

Anti-HAUSP/USP7 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-HAUSP/USP7 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Deubiquitinating enzyme 7 antibody, HAUSP antibody, Herpes virus associated ubiquitin specific protease antibody, Herpesvirus-associated ubiquitin-specific protease antibody, TEF 1 antibody, tef-1 antibody, TEF1 antibody, Ubiquitin carboxyl terminal hydrolase 7 antibody, Ubiquitin carboxyl-terminal hydrolase 7 antibody, Ubiquitin specific peptidase 7 (herpes virus associated) antibody, Ubiquitin specific peptidase 7 antibody, Ubiquitin specific peptidase 7 herpes virus associated antibody, Ubiquitin specific processing protease 7 antibody, Ubiquitin specific protease 7 (herpes virus associated) antibody, Ubiquitin specific protease 7 antibody, Ubiquitin specific protease 7 herpes virus associated antibody, Ubiquitin thioesterase 7 antibody, Ubiquitin thiolesterase 7 antibody, Ubiquitin-specific-processing protease 7 antibody, UBP 7 antibody, UBP-7 antibody, UBP7 antibody, UBP7_HUMAN antibody, USP 7 antibody, usp-7 antibody, Usp7 antibody, VMW110-ASSOCIATED PROTEIN, 135-KD antibody

Database links

UniProt/Swiss-Prot:Q93009

Protein function

Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN and DAXX (PubMed:11923872, PubMed:15053880, PubMed:16964248, PubMed:18716620, PubMed:25283148). Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53-dependent transcription regulation, cell growth repression and apoptosis (PubMed:25283148). Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6. Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection. Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, preventing their degradation and promoting DNA methylation by DNMT1 (PubMed:21745816). Exhibits a preference towards ‘Lys-48’-linked ubiquitin chains. Increases regulatory T-cells (Treg) suppressive capacity by deubiquitinating and stabilizing the transcription factor FOXP3 which is crucial for Treg cell function (PubMed:23973222). .

Protein tissue specificity

Widely expressed. Overexpressed in prostate cancer. .

Protein sequence and domain

Belongs to the peptidase C19 family. ; Contains 1 MATH domain. ; Contains 1 USP domain. The C-terminus plays a role in its oligomerization.

Protein post-translational modifications

Isoform 1: Phosphorylated. Isoform 1 is phosphorylated at positions Ser-18 and Ser-963. Isoform 2: Not phosphorylated. .; Isoform 1: Polyneddylated. Isoform 2: Not Polyneddylated.; Isoform 1 and isoform 2: Not sumoylated.; Isoform 1 and isoform 2: Polyubiquitinated by herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110; leading to its subsequent proteasomal degradation. Isoform 1: Ubiquitinated at Lys-869. .

Protein cellular localization

Nucleus . Cytoplasm . Nucleus, PML body . Note=Present in a minority of ND10 nuclear bodies. Association with ICP0/VMW110 at early times of infection leads to an increased proportion of USP7-containing ND10. Colocalizes with ATXN1 in the nucleus. Colocalized with DAXX in speckled structures. Colocalized with PML and PTEN in promyelocytic leukemia protein (PML) nuclear bodies.

Research area

All research areas>Synthesis and Degradation>HAUSP
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize Anti-HAUSP/USP7 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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