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Mouse Monoclonal Anti-HDAC3 antibody (STJ99157)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-HDAC3 antibody.
Check alternative names for the antibodyExpand
|HD3 antibody|HDAC 3 antibody|HDAC3 antibody|HDAC3_HUMAN antibody|Histone deacetylase 3 antibody|RPD3 2 antibody|RPD3 antibody|RPD3-2 antibody|SMAP45 antibody|Anti-HDAC3 antibody [Y415] (ab32369)
SCBT cat No: sc-130319|sc-81600|sc-136290|sc-376957|sc-17795|sc-11417|sc-8138|
|Catalogue No.|| |
Human, Mouse, Rat
Anti-HDAC3 antibody detects endogenous levels of HDAC3 and does not cross-react with related proteins.
Purified recombinant human HDAC3 protein fragments expressed in E.coli.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-HDAC3 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-HDAC3 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
HD3 antibody, HDAC 3 antibody, HDAC3 antibody, HDAC3_HUMAN antibody, Histone deacetylase 3 antibody, RPD3 2 antibody, RPD3 antibody, RPD3-2 antibody, SMAP45 antibody
|Database links|| |
|Protein function|| |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 ‘Lys-27’ (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803). .
|Protein tissue specificity|| |
|Protein sequence and domain|| |
Belongs to the histone deacetylase family. HD type 1 subfamily.
|Protein post-translational modifications|| |
Sumoylated in vitro. .
|Protein cellular localization|| |
Nucleus . Cytoplasm . Cytoplasm, cytosol . Note=Colocalizes with XBP1 and AKT1 in the cytoplasm (PubMed:25190803). Predominantly expressed in the nucleus in the presence of CCAR2. .
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St John’s Laboratory Ltd.
|Product type|| |
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