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Mouse Monoclonal Anti-HDAC4 antibody (STJ99035)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-HDAC4 antibody.
Check alternative names for the antibodyExpand
|AHO3 antibody|BDMR antibody|EC 126.96.36.199 antibody|HA6116 antibody|HD 4 antibody|HD4 antibody|HDAC 4 antibody|HDAC A antibody|HDAC4 antibody|HDAC4_HUMAN antibody|HDACA antibody|Histone deacetylase 4 antibody|Histone Deacetylase A antibody|KIAA0288 antibody|Anti-HDAC4 antibody (ab12172)
SCBT cat No: sc-46672|sc-365093|sc-48390|sc-365367|sc-11418|sc-56686|sc-5246|sc-5245|sc-11421|
|Catalogue No.|| |
Anti-HDAC4 antibody detects endogenous levels of HDAC4 and does not cross-react with related proteins.
Purified recombinant human HDAC4 protein fragments expressed in E.coli
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-HDAC4 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-HDAC4 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
AHO3 antibody, BDMR antibody, EC 188.8.131.52 antibody, HA6116 antibody, HD 4 antibody, HD4 antibody, HDAC 4 antibody, HDAC A antibody, HDAC4 antibody, HDAC4_HUMAN antibody, HDACA antibody, Histone deacetylase 4 antibody, Histone Deacetylase A antibody, KIAA0288 antibody
|Database links|| |
|Protein function|| |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. .
|Protein tissue specificity|| |
|Involvement in disease|| |
Brachydactyly-mental retardation syndrome (BDMR) [MIM:600430]: A syndrome resembling the physical anomalies found in Albright hereditary osteodystrophy. Common features are mild facial dysmorphism, congenital heart defects, distinct brachydactyly type E, mental retardation, developmental delay, seizures, autism spectrum disorder, and stocky build. Soft tissue ossification is absent, and there are no abnormalities in parathyroid hormone or calcium metabolism. . Note=The gene represented in this entry is involved in disease pathogenesis. HDAC4 point mutations and chromosomal microdeletions encompassing this gene have been found in BDMR patients (PubMed:20691407, PubMed:24715439, PubMed:23188045). However, HDAC4 haploinsufficiency is not fully penetrant and multiple genes may contribute to manifestation of the full phenotypic spectrum (PubMed:24715439, PubMed:23188045). .
|Protein sequence and domain|| |
Belongs to the histone deacetylase family. HD type 2 subfamily. The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm.; The PxLPxI/L motif mediates interaction with ankyrin repeats of ANKRA2.
|Protein post-translational modifications|| |
Phosphorylated by CaMK4 at Ser-246, Ser-467 and Ser-632. Phosphorylation at other residues by CaMK2D is required for the interaction with 14-3-3. Phosphorylation at Ser-350, within the PxLPxI/L motif, impairs the binding of ANKRA2 but generates a high-affinity docking site for 14-3-3. .; Sumoylation on Lys-559 is promoted by the E3 SUMO-protein ligase RANBP2, and prevented by phosphorylation by CaMK4. .
|Protein cellular localization|| |
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation.
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St John’s Laboratory Ltd.
|Product type|| |
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