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Mouse Monoclonal Anti-HP1-alpha antibody (STJ99039)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-HP1-alpha antibody.
Check alternative names for the antibodyExpand
|Antigen p25 antibody|CBX5 antibody|CBX5_HUMAN antibody|CG8409 antibody|Chromobox 5 antibody|Chromobox homolog 5 (HP1 alpha homolog, Drosophila) antibody|Chromobox homolog 5 antibody|Chromobox protein homolog 5 antibody|Epididymis luminal protein 25 antibody|HEL25 antibody|Heterochromatin protein 1 alpha antibody|Heterochromatin protein 1 antibody|Heterochromatin protein 1 homolog alpha antibody|HP1 alpha antibody|HP1 alpha homolog antibody|HP1 antibody|HP1A antibody|HP1Hs alpha antibody|Su(var)205 antibody|Anti-HP1 alpha antibody – ChIP Grade (ab77256)
SCBT cat No: sc-10217|sc-10215|sc-28735|sc-10210|sc-30742|sc-130446|sc-30743|
|Catalogue No.|| |
Anti-HP1-alpha antibody detects endogenous levels of HP1 alpha and does not cross-react with related proteins.
Purified recombinant human HP1 alpha protein fragments expressed in E.coli.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-HP1-alpha antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-HP1-alpha antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Antigen p25 antibody, CBX5 antibody, CBX5_HUMAN antibody, CG8409 antibody, Chromobox 5 antibody, Chromobox homolog 5 (HP1 alpha homolog, Drosophila) antibody, Chromobox homolog 5 antibody, Chromobox protein homolog 5 antibody, Epididymis luminal protein 25 antibody, HEL25 antibody, Heterochromatin protein 1 alpha antibody, Heterochromatin protein 1 antibody, Heterochromatin protein 1 homolog alpha antibody, HP1 alpha antibody, HP1 alpha homolog antibody, HP1 antibody, HP1A antibody, HP1Hs alpha antibody, Su(var)205 antibody
|Database links|| |
|Protein function|| |
Component of heterochromatin that recognizes and binds histone H3 tails methylated at ‘Lys-9’ (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when ‘Tyr-41’ of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. .
|Protein sequence and domain|| |
Contains 2 chromo domains.
|Protein post-translational modifications|| |
Phosphorylation of HP1 and LBR may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle (By similarity). Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis. .; Ubiquitinated. .
|Protein cellular localization|| |
Nucleus . Chromosome . Chromosome, centromere . Note=Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase.
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St John’s Laboratory Ltd.
|Product type|| |
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