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Mouse Monoclonal Anti-HTRA2 antibody (STJ99217)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-HTRA2 antibody.
Check alternative names for the antibodyExpand
|High temperature requirement protein A2 antibody|HTRA 2 antibody|HtrA like serine protease antibody|HtrA serine peptidase 2 antibody|HtrA, E. coli, homolog of, 2 antibody|HtrA2 antibody|HTRA2_HUMAN antibody|mitochondrial antibody|Omi stress regulated endoprotease antibody|Omi stress-regulated endoprotease antibody|PARK 13 antibody|PARK13 antibody|Protease serine 25 antibody|PRSS 25 antibody|PRSS25 antibody|Serine protease 25 antibody|Serine protease HTRA2 antibody|Serine protease HTRA2 mitochondrial antibody|Serine protease htra2 mitochondrial precursor antibody|Serine protease omi antibody|Serine proteinase OMI antibody|Anti-HtrA2 / Omi antibody [E55] (ab32092)
SCBT cat No: sc-58371|sc-271528|sc-365594|sc-25606|sc-15467|
|Catalogue No.|| |
Anti-HTRA2 antibody detects endogenous levels of HtrA2/Omi and does not cross-react with related proteins.
Recombinant human HtrA2/Omi protein.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
Anti-HTRA2 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-HTRA2 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
High temperature requirement protein A2 antibody, HTRA 2 antibody, HtrA like serine protease antibody, HtrA serine peptidase 2 antibody, HtrA, E. coli, homolog of, 2 antibody, HtrA2 antibody, HTRA2_HUMAN antibody, mitochondrial antibody, Omi stress regulated endoprotease antibody, Omi stress-regulated endoprotease antibody, PARK 13 antibody, PARK13 antibody, Protease serine 25 antibody, PRSS 25 antibody, PRSS25 antibody, Serine protease 25 antibody, Serine protease HTRA2 antibody, Serine protease HTRA2 mitochondrial antibody, Serine protease htra2 mitochondrial precursor antibody, Serine protease omi antibody, Serine proteinase OMI antibody
|Database links|| |
|Protein function|| |
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive. .
|Protein tissue specificity|| |
Isoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid.
|Involvement in disease|| |
Parkinson disease 13 (PARK13) [MIM:610297]: A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. . Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the peptidase S1C family. ; Contains 1 PDZ (DHR) domain. The mature N-terminus is involved in the interaction with XIAP.; The PDZ domain mediates interaction with MXI2.
|Protein post-translational modifications|| |
|Protein cellular localization|| |
Mitochondrion intermembrane space. Mitochondrion membrane ; Single-pass membrane protein . Note=Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID.
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St John’s Laboratory Ltd.
|Product type|| |
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